Description:

Backed by Science to Help Optimize:

• Dairy Free, Soy Free, Gluten Free, Non-GMO*
• Promotes Muscles Growth & Repair*
• Easily Digested*
• Highest Quality Alternative to Soy, Whey & Milk Protein*

A NO B.S. Formulation, Backed by Science.

VEG-PRO is a Non-GMO Verified Vegan Protein powder delivering 20g of dairy free protein complete profile of all the essential amino acids. VEG-PRO is gently produced at low temperatures, without any added fillers or carriers, ensuring the preservation of its complete amino acid integrity.

Ingredients:

Glutamic Acid, Aspartic Acid, Leucine, Arginine, Valine, Alanine, Phenylalanine, Tyrosine, Serine, Proline, Glycine, Isoleucine, Threonine, Methionline, Lysine, Cysteine, Histidine.

Other Ingredients: Brown Rice Protein, Pea Protein Isolate, D-Ribose, Maltodextrin, Beet Root Extract, Natural Flavors, Xanthan Gum, Stevia Extract (95% Steviol Glycosides), Silicon Dioxide.

FAQs:

Q. How do I take VEG-PRO?

A. Mix 1 scoop of VEG-PRO in 6-8oz of water. Shake vigorously. Each serving provides 24 grams of protein.

Q. What is the difference between WHEY-PRO, WHEY-ISO AND VEG-PRO?

A. WHEY-ISO is lactose free and filtered, WHEY-PRO is filtered but still has traces of dairy and a thicker consistency, VEG-PRO is plant derived and great for those with sensitive stomachs.

Description:

• 25G WHEY PROTEIN ISOLATE
• FAST DIGESTING
• LOW CARB / LOW FAT
• GLUTEN FREE

ISO-Protein™, sets the standard for high quality whey protein isolate! ISO-Protein has quickly become the industry’s leading protein powder.*

ISO-Protein™ contains super-premium 90% Whey Protein Isolate in an instantized powder for easy mixability with OUT OF THIS WORLD TASTE! During manufacturing, proprietary membrane techniques are used to yield a highly pure, nutritionally superior and undenatured isolate protein powder. ISO-Protein™ features full protein ingredient disclosure, not only telling you the total protein used but also the yielding or complete protein (the protein your body actually uses!).

SUPER-PREMIUM 90% WHEY PROTEIN ISOLATE!

Not all isolate protein powders are created equal. We only use the highest yielding instantized whey protein isolate in ISO-Protein™. This means 90% of the total isolate protein is complete or usable protein, the highest yield available on the market.

OUT OF THIS WORLD TASTE & MIXABILITY!

Taste and mixability isn’t everything but it plays a huge part in the user experience. It’s much easier to stick to a supplement regimen when you actually enjoy (or crave!) what you’re drinking! ISO-Protein™ comes in easy to mix, super-delicious Blueberry Muffin, Peanut Butter Bits and classics like Chocolate Milk & Vanilla Ice Cream.

Allergen Warning: This product is manufactured with equipment that process products that may contain milk, egg, soy, tree nuts, peanuts, wheat, fish, crustaceans & shellfish. Contains milk and soy (as soy lecithin).

Clean Protein does not contain soy protein.

STORE IN A COOL, DRY PLACE. CONTENTS SOLD BY NET WEIGHT, NOT VOLUME, SOME SETTLING MAY OCCUR.

Suggested Use: Add 1 heaping scoop of ISO-PROTEIN in 8oz of cold water or milk. Make sure to shake well for full mixability, we recommend using a shaker cup. You can vary the amount of liquid based on the consistency and taste you desire. Consume 1 serving of ISO-PROTEIN within 30 minutes of your workout. You can also consume ISO-PROTEIN throughout the day based on your desired protein intake requirements.

Description

THE REVOLUTIONARY'S PROTEIN

Description:

Description:

Core Nutritionals’ Core BURN Ultra powder is that better way. There are no gimmicks here, no tricks and trade secrets. Just the very best, most verified-effective ingredients at serving sizes known to exert powerful effects on the human body. With Core BURN Ultra, we have taken many of the same ultra-potent ingredients found in Core BURN, mixed in a few amazing new friends, and put the whole thing in a delicious, convenient, and rapidly-dissolving powder. In the end, it’s your choice: flashy magazine ads, or an unrivaled and extreme thermo that plain, flat-out works as promised. If we had to choose between a slim wallet or a slim waist, we’d choose the latter – because we’d choose Core BURN Ultra. 

Highlighted Ingredients of Core Burn Ultra:

• Garcinia Cambogia Fruit Extract
• Green Coffee Extract
• Coleus Forskohlii Root Extract
• Advantra-Z Orange Extract

Description:

• SUPPORTS FAT BURNING*
• PROVIDES NATURAL ENERGY*
• STIMULANT FREE
• ZERO SUGAR, CALORIES & CARBS

Description:

Drop the kitchen sink approach and get surgical.

Core BURN is formulated with a diverse range of proven ingredients to create a powerful, balanced, and effective product. Core BURN is designed to target precise primary and secondary metabolic pathways, at multiple targets, to ensure maximum weight management.

• 2-3 capsules per serving.
• 75-50 servings per container.
• Jitter-free weight management.

Every week, there is a new story about a “breakthrough” or “miracle” substance that will make every other ingredient before it obsolete. Some of these claims may have merit, but the truth is that the biochemical processes of lipolysis are very complex and tightly regulated by the endocrine system and other biochemical pathways. Navigating this maze to effectively manage weight and body composition therefore requires more than a single, “miracle” compound: it involves numerous agents that together activate certain metabolic functions, while suppressing others. No single, “magic” compound does the job alone.

Core BURN is formulated to drop the kitchen sink and “miracle” ingredient tactics, and instead uses a diverse range of proven ingredients to create a powerful, balanced, and effective product. Core BURN is designed to target precise primary and secondary metabolic pathways, at multiple targets, to ensure maximum effectiveness. No more playing darts in the dark when it comes to weight management categories; randomly including ingredients, in whatever servings, hoping that something works. Specific. Multi-targeted. These words exemplify the new approach: amazing ingredients, in clinically-reflected serving sizes, all included in a non-proprietary blend so you know exactly what you’re consuming. 

Ingredients:

Acetyl-l-Carnitine:

L-carnitine is a derivative of the amino acid lysine and, as certain conditions outpace the body’s ability to produce it, l-carnitine is considered a conditionally essential amino acid. While endogenous biosynthesis of l-carnitine from the amino acids lysine and methionine is sufficient for essential processes – along with dietary sources of carnitine from protein-rich red meat, for example – dietary supplementation of carnitine may pose benefits in certain physiological conditions.

Unfortunately, due to excess metabolism of l-carnitine by microorganisms in the small intestine, exogenous supplementation with oral l-carnitine has proved ineffective. ALCAR, an acetylated version of l-carnitine, has considerably higher oral bioavailability, due likely to only partial hydrolytic metabolism. Once in the bloodstream, ALCAR plays a fundamental role in the production of energy, acting as the catalyst for the beta-oxidation of long chain fatty acids by the mitochondria; regulating the CoA to Acyl-CoA ratio (necessary for the production of ATP); and the metabolism of carbohydrates. ALCAR also is an excitatory agent for neurons, increases neuronal transmission, and increases the production of neurotransmitters and neurohormones such as dopamine and serotonin.

Green Tea Extract (Camilla sinensis) (leaf) (50% EGCG):

Along with caffeine from the coffee plant, EGCG (Epigallocatechin gallate) from various sub-species of Camilla sinesis (green tea) is perhaps the most widely known and reputable anti-lipogenic and lipolytic agent in the world. Both compounds have well established anti-obesity effects, detailed in a deep body of literature featuring in vitro cell culture, as well as in vivo animal and human trials.

In animal and human studies, green tea generally and EGCG more specifically has been demonstrated to reduce the absorption of dietary lipids and modulate their subsequent metabolism, increase glucose utilization in resting states, as well as initiate de novo lipogenesis in both maximal and submaximal exercise states.

A two month dietary intervention, for example, showed that the daily consumption of a catechin-rich tea – EGCG is the most well-known of the catechins – by healthy humans led to a reduction of bodyweight of up to 20%, the consequence of increased lipolysis (as measured by FFA urinary clearance). A separate double-blind, placebo controlled trial using EGCG consumption both with, and without caffeine, demonstrated the increased oxidation of fatty acids within two hours of a meal – at level increases of 49% and 35%, respectively.

These studies suggest that EGCG not only exerts an inhibitory effect on the accumulation of lipids, but that it perhaps actively leads to the hydrolyzation of triglycerides for use as energy in the form of FFAs. In particular, this effect seems to be potentiated in the presence of caffeine ingestion, suggesting a synergistic effect between EGCG and caffeine on the hydrolyzation and subsequent oxidation of triglyceride stores.

Green Coffee Extract (Coffee arabica) (bean) (50% chlorogenic acid):

Chlorogenic acids (CGAs) are phenolic compounds created during the metabolism of various isoquinic acids found in the leaves of both coffee and tea. In addition to the well-established sympathomimetic effects of coffee and tea’s constituents, recent research has demonstrated a range of other potential benefits for compounds such as chlorogenic acids.

Recent literature suggests that the consumption of both green coffee, as well as standardized extracts of CGAs, relax the vasculature and improve vasoreactivity, impose an inhibitory effect on lipid accumulation and body weight in both mice and humans, and modulate glucose metabolism via the glucose-6-phosphate pathway.

Trials in both humans and mice using 1% extracts of green coffee bean revealed significant bodyweight reductions over periods of two and eight weeks. Researchers hypothesized that the bodyweight reductions associated with oral CGA administration was associated with the products numerous mechanisms of action, rather than a single, isolated cause.

Olive Extract (Olea europaeai) (leaf) (20% oleuropein):

Olea europaea, more commonly known as the olive, is a species of a small tree in the family Oleaceae, native to the coastal areas of southeastern Europe, western Asia and northern Africa, as well as northern Iran at the south end of the Caspian Sea.

As the fruits, oils, and extracts of Olea europaea L. are a dietary component for a significant portion of the world’s population, the plant has become associated with a wide-range of physiologic and metabolic benefits. These properties are largely attributed to the phenolic compounds of olive leaves, including: caffeic acid, verbascoside, oleuropein, luteolin 7-O-glucoside, rutin, apigenin 7-Oglucoside, and luteolin 4′-O-glucoside. Collectively, these olive polyphenols are responsible for a wide-range of postulated health benefits.

Oleuropein, in particular, is purported to have several pharmacological properties including antioxidant, anti-inflammatory, anti-atherogenic, and anti-microbial effects. Recent research in animals has also demonstrated that oleuropein may potentiate the response of 5'-deiodinase, the enzyme responsible for the irreversible conversion of thyroxine (T4) into triiodothyronine (T3), the active thyroid hormone.

Caffeine (1,3,7-trimethylxanthine) and Theomobrine (3,7-dimethyl-1H-purine-2,6-dione):

Caffeine is the most widely consumed, and perhaps one of the most reviewed, psychoactive compounds. Its physiological effects in a range of areas have been well-documented, including exercise performance, information processing, alertness and mood enhancement, attention, and awareness, along with its anti-lipogenic and lipolytic abilities. Caffeine is also the most well-known in the methylxanthine compound class, the constituents of which inter-metabolize into one another in the human body and largely share similar effects.

Various clinical trials have demonstrated that xanthines – including caffeine and theobromine – exert potent lipolytic (the breakdown of triglycerides into fatty acids) and oxidative actions as sympathomimetic amines. In less scientifically-complex parlance, this means caffeine is forcing your body to preferentially use adipose tissue as a fuel source for the oxidative provision of ATP (your body’s energy currency).

Evidence for xanthine’s capacity as lipolytic agents is widely available. In a clinical study featuring four separate trials in both normal and obese subjects, for example, caffeine was found to significantly increase fatty acid metabolism (as measured by serum fatty acid concentration), resting metabolic rate, and total fat oxidation – suggesting the preferential substrate selection spoken about above occurs in both normal and obese individuals. Other trials have demonstrated the effects of methylxanthines on total fat mass (reduction), lean body mass (increases), stamina and endurance, as well as cardiovascular capacity.

Additionally, as selective cAMP potentiators, through the beta-adrenergic pathway, caffeine and theobromine have been hypothesized to exert a synergistic effect on lipolysis when combined with forskolin.

Bacopa monnieri Extract (whole plant) (50% bacosides):

Bacopa monnieri (BM), also known as the water hyssop commonly, or as Brahmi in Ayurvedic texts, is a small creeping herb endemic to sub-tropical India. The herb has been used in traditional Indian medicine for well over one thousand years, with its first recorded usage coming in the 6^th century A.D. In this traditional context, BM has been used for a wide-range of purposes, including as a treatment of asthma and epilepsy.

More recently, BM has been the subject of numerous cognition and memory trials, as the plant has a well-established nootropic effect. Likely through modulation of the serotonin reuptake system, clinical trials in healthy human beings have demonstrated that BM possesses a significant effect on the retention of newly-learned information. In several trials utilizing a 300mg daily serving, BM was also shown to decrease the recall delay of newly learned information and reduce short term forgetfulness – suggesting that the herb’s effect on the serotonic and cholinergic systems are increasing the encoding (the literal storing) of memory information.

Beyond cognition and memory encoding, BM has also been demonstrated to function as a potent adaptogen and relaxant – which in the Core BURN formula may help to smooth the effect curve of the product’s stimulants, reducing jitteriness or “crash.”

ForsLean® (Coleus forskohlii) (root) (20% forskolin): Coleus forskohlii is a small perennial endemic to various tropical regions in the world, including South America, sub-Saharan Africa, and India. While the West has recently taken interest in the plant due to the pharmacological properties of its primary bioactive, forskolin, Coleus forskholii preparations and tinctures have been used in both South American and African traditional folk medicinal systems, as well as extensively within Ayurveda.

Due to the ever-increasing interest in the plant’s verifiable pharmacological and physiological effects, however, Coleus forksholii and its extracted constituents have been the subject of numerous animal and human clinical trials in the past decade, primarily in its patented form of ForsLean. These trials have demonstrated the plant to have various effects and applications, including as a lipolytic and anti-lipogenic, and as a powerful antioxidant.

A recent double-blind, randomized, and placebo-controlled human clinical trial featuring obese men found that the daily implementation of ForsLean, for twelve weeks, led to significantly better weight loss outcomes as compared to controls. Overweight men in the ForsLean group experienced not only improved body composition (as measured by total non-lean mass), but also statistically significant increases in lean body mass.

In a separate 8 week trial, in overweight females, ForsLean was found to significantly reduce total bodyweight and significantly increase lean body mass relative to controls. Weight loss was statistically significant after 4 and 8 weeks and the mean amounted to 4.3 and 9.17 lbs respectively.

ForsLean – and more specifically, forskolin – achieves this effect by rapidly, potently, and dose-dependently increasing an important metabolic enzyme known as adenylate cyclase. Adenylate cyclase is an enzyme responsible for catalyzing the formation of cyclic adenosine monophosphate (cAMP) from adenosine triphosphate (ATP). This increase in cAMP formation eventually leads to the activation of an enzyme, protein kinase A, which in turn will phosphorylate and hence activate the enzyme, Hormone Sensitive Lipase (HSL) – the rate-limiting enzyme necessary for stored triglycerides within adipocytes to be released as free fatty acids and utilized for energy.

In more basic terms, this means that forskolin quite literally frees up more fatty acids to be used as fuel for exercise – more or less the perfect scenario in a product such as Core BURN!

Yohimbe Extract (Pausinystalia yohimbe) (bark) (8% Yohimbine alkaloids):

Extracts or preparation of Pausinystalia yohimbe, and related sub-species, have been used in traditional and folk medicinal systems such as Ayurveda and Unani for centuries. More recently, the principal bioactive compound in Pausinystalia yohimbe, both as a whole plant, and its extracted components, has been the subject of numerous clinical trials investigating its various physiological pathways.

In particular, recent research has shown that yohimbe bark extracts exert a powerful pre-synaptic inhibiting effect on alpha-adrenergic receptors – making it a potent adrenergic antagonist. This effect seems to be localized and largely specific to adipocytes, attaching to their adrenergic receptor sites and preventing them from receiving the catecholamines (norepinephrine and epinephrine) that would normally initiate growth signals.

While limited, there is some evidence in human, clinical trials to suggest that Yohimbine’s postulated mechanisms of action translate into practical effects. In a placebo-controlled trial involving 20 healthy, lean soccer players, subjects were given 20mg/day in two equal servings, for 21 days. At 21 days, the Yohimbine group reflected small but significant reductions in both total fat mass and bodyfat percentage as compared to controls – at least partially suggesting that Yohimbine may have a plausible role in combination with diet and exercise in weight management.

Advantra-Z® Bitter Orange Extract (Citrus aurantium) (fruit) (50% synephrine):

Synephrine is a naturally-occurring alkaloid with adrenergic agonist activity, structurally related to epinephrine, norepinephrine, ephedrine, and other compounds with a phenethylamine base structure. Despite its chemical similarity to these compounds, synephrine in its various isomers exerts unique effects on adrenergic receptors, in particular, and the human body, in general.

Synephrine exists in three isomer forms: para-, meta- and ortho-synephrine. The molecular changes between the three isoforms are minute, but even this small change results in significant alterations to each isomer’s physiological and pharmacokinetic profile. Two of synephrine’s isomers, both p- and m-synephrine, have been shown to naturally occur in mammals (in low concentrations). As a sympathomimetic, synephrine has been the subject of numerous trials, assessing its effects on weight management, thermogenesis, metabolic rate, and caloric expenditure. In a double-blind, randomized, and placebo-controlled trial involving 10 healthy individuals, the p-synephrine isomer was administered at a 50mg serving, both alone, and in combination with hesperidin and naringin. The authors measured resting metabolic rate (RMR), blood pressure, and heart rate, along with subjective feelings of mood and energy, at baseline, and at 45-mintues and 75-minutes after ingestion. The authors reported a significant increase in RMR in each of the supplement groups, relative to placebo.

In addition to studies on synephrine in its various isomers, Advantra-Z®, the specific form of synephrine utilized in Core BURN, has itself and in combination with other ingredients, been the subject of various clinical trials in humans. In a randomized, double-blind, placebo-controlled trial featuring 70 obese adults, a formulation containing Advantra-Z® was found to significantly reduce fat mass, body weight, and hip and waist girth as compared to controls, while leading to an increase in lean mass. As the authors comment, these results are in-line with a recent systematic review of human clinical studies involving Citrus aurantium, that revealed the ingredient to reliably increase resting metabolic rate up to 7.2%, increase energy expenditure of up to 13.4%, and weight loss of over 2.9 kg, with no serious adverse events in any of the trials.

In addition, the combination of caffeine and synephrine appears to potentiate each ingredient’s effects – with rates of fatty acid liberation, heart rate, metabolic rate, and fatty acid oxidation increased in clinical trials featuring the combination. In the same systematic review mentioned above, the authors note that the combination of synephrine and caffeine led to a small but significant reduction in fat mass of 3lbs, and a reduction in bodyfat of 2.9%.

Combined with not only caffeine, but the other ingredients in Core BURN, Advantra-Z® appears to be a potent weapon in the arsenal for body composition and weight management.

References:

For references, see below file;

Core Nutritionals: SHRED References

Description:

Description:

It’s been called the most important meal of the day.

Eating high quality, fast-acting carbohydrates and protein create the conditions for growth after a workout. Core PWO takes the guesswork out of post workout recovery, containing the fast-acting proteins and carbs needed to maximize muscle recovery after weight training.

• 2 scoops per serving.
• 28 servings per container.
• High carb for maximum recovery.

It has been called the most important meal of the day, “the anabolic window,” and eating for anabolism. Whatever name you give it, the premise remains: post workout (PWO) nutrition is crucial to reaching your fitness and physique goals. Post workout nutrition plays a number of critical anabolic (tissue building) functions, chief among them the maximization of glycogen storage and protein synthesis, while simultaneously minimizing protein breakdown and the excessive release of catabolic (tissue destroying) hormones.  Incomplete or insufficient PWO nutrition is like fueling your new Maserati with regular unleaded – you simply don’t do it. 

This all raises the question: what is the ideal post workout nutrition? Is it well known, or a secret? Maybe a certain ratio of carbohydrates to protein, or fat to protein; maybe the timing and frequency? In fact, the situation is vastly less complex, more well-known, and easier to implement than most would have you believe. 

High quality, fast-acting carbohydrates and protein have been shown time and again to induce the most optimal conditions for growth in clinical studies – and that is precisely what Core has attempted to emulate with Core PWO. Core PWO takes the guesswork out of post workout recovery, containing the fast-acting proteins and carbs (whey isolate, dextrose, Carb10™ and Cluster Dextrin®), along with other anabolic agents (free-form L-Leucine and Velositol®) needed to maximize muscle recovery after weight training. These ingredients quickly replenish muscle glycogen and shuttle much needed amino acids to muscle cells. Whether you are bulking up or slimming down, all of these ingredients are crucial for proper recovery.

Ingredients:

Recovery Carb Blend (Dextrose, Carb 10™ and Cluster Dextrin®):

As mentioned above, one of the main goals post workout is to restore muscle glycogen that has been depleted during the workout. The body will even break down muscle tissue for this purpose if an adequate influx of glucose – obtained from the consumption of carbohydrates – is not provided. For this reason, it is vital to include carbohydrates in the post-workout drink.

Though opinion varies, the scientific literature is relatively clear that fast–digesting carbohydrates such as dextrose, Carb 10™, and Cluster Dextrin® create optimal conditions for the post-workout synthesis of both skeletal muscle protein and muscle glycogen. Not only have all three of Core PWO’s carbohydrates sources demonstrated higher rates of post-exercise glycogenesis (glycogen resynthesis) as compared to other carbohydrate sources, they have also been shown to optimize insulin response and blunt cortisol release to a greater degree than other carbohydrate sources.

Dextrose functions at such a higher capacity because of molecular structure, given that it is otherwise known as pure glucose – your body’s preferred energy substrate and the necessary component for the synthesis and resynthesis of glycogen. Bypassing the lengthy and metabolically costly process of digestion and breakdown, dextrose can be absorbed directly through the gut into the bloodstream and can cause an insulin response faster than any other carb. Additionally, since dextrose is already in the form the body requires, it can be used immediately for glycogen replenishment.

Carb10™ is an entirely different creature, which functions in PWO to round out the insulin response. Created not from maltodextrin or glucose, but rather peas, Carb10™ is a clean and sustained means of providing your body with its nutritional needs in the post workout environment. Carb10™ also possesses low osmolality, a term used to describe the concentration of a solution. In this case, low osmolality means that Carb10’s transit through the stomach and into the intestine’s is both quicker and more efficient than other carbohydrates sources – meaning it delivers nutrients quickly, while still being low glycemic and reducing bloat. Think of it like other carbohydrates causing a traffic jam, while Carb10™ cruises through the carpool lane.

In total, Carb10™ possesses a wide range of benefits. Including:

• Minimal blood-sugar and insulin response
• Fast gastric-emptying formula reduces bloating
• Low osmolality
• Prebiotic, non-allergenic, non-GMO and gluten-free.

Cluster Dextrin®, the last of PWO’s carb sources, is derived from corn. Though dissimilar in molecular structure and source from Carb10™, it’s similar in terms of its low osmolality leading to expedient stomach clearing and low bloating. Research conducted on top swimmers, swimming in a flowing water pool, confirmed that Cluster Dextrin’s fast gastric emptying contributed to increased endurance (longer swim times). Swimmers provided a sports drink containing Cluster Dextrin had approximately 50% longer swim time than swimmers provided a mixture of water and glucose only.

In combination, the carbohydrates in Core PWO, in their precise serving sizes, interact to form a comprehensive post-workout nutrition strategy:

• Dextrose acts quickly to create an immediate supply of glucose and to stimulate post-workout insulin levels.
• Due to their molecular structure, Carb-10™ and Cluster Dextrin balance that insulin response.
• Together, they all rapidly, and in a sustained fashion, provide your body with a prime environment for the synthesis of both glycogen and skeletal muscle
• And most importantly, they do so without the bloat!

Clinical research is clear that carbohydrates of this type, in combination with whey protein isolate, rapidly reverse high levels of cortisol and low levels of insulin that are associated with high intensity exercise. The rapid, but very beneficial, influx of glucose from oral carbohydrate supplementation quickly suppresses cortisol and the negative effect it has on the expression of metabolically critical proteins and growth factors – ensuring that myocytes (muscle cells) function in an ideal environment. In addition, these carbohydrates induce a beneficial insulin response, the effects of which include stimulating glycogen storage, the transport of glucose into muscle cell mitochondria, and an increase in amino acid utilization.

Cold-Processed Microfi­ltered Non-GMO Whey Protein Isolate:

If the post-workout environment were a jungle, whey protein isolate would be the lion – its king. While it is difficult to overstate the critical role that post-exercise protein consumption plays in both a macro (body composition) and micro (small-scale, physiological changes) context, some ambiguity remains: what is the ideal form, frequency, timing, and amount of protein consumption post-exercise? Luckily for you, Core Nutritionals’ research hounds have crunched the numbers and read the studies for you, and the result is a very precise amount of whey protein isolate included in Core PWO.

In a statement that should not surprise a single athlete or casual weightlifter, intense resistance training has a profound effect on the function and structure of skeletal muscle and muscle proteins. Immediately following an intense bout of resistance exercise, a process known as muscle protein breakdown – with its sidekick, leucine oxidation – begin to literally tear down your skeletal muscle from the inside. While resistance training simultaneously increases a process known as protein synthesis, the fractional synthesis rate (how quickly the protein is synthesized) is often far exceeded by the rate of muscle protein breakdown and leucine oxidation. The result is that, in that absence of mitigating factors such as post-workout nutrition, your body is in a state of negative protein balance – i.e., catabolism.

In order to counteract a negative intramuscular protein balance, a number of things need to occur – mostly, a rapid increase in the availability of amino acids, and the optimization of several metabolically critical hormones (such as insulin). The combination of protein and carbohydrates contained in Core PWO achieves precisely this balance, and research on whey protein and dextrose in combination demonstrates that this combination maximizes the stimulation of muscle protein synthesis and results in even greater muscle anabolism than either alone.

Free Form Leucine:

The branch-chained amino acids leucine, isoleucine, and valine are famous for their role in skeletal muscle protein synthesis and metabolism, and additionally comprise approximately one-third of all skeletal muscle protein. Of the three, leucine is both the most physiologically important with respect to muscle mass, and the most extensively studied. Data on leucine demonstrate this amino acid plays critical roles in stimulating skeletal muscle protein synthesis, and ribosomal biogenesis and assembly (the literal building of muscle tissue), along with playing a lesser role in insulin signaling and gluconeogenic processes. As a result of these diverse roles, leucine has been demonstrated to significantly stimulate skeletal muscle protein synthesis, and attenuate protein degradation, by both insulin-mediated and non-insulin mediated mechanisms.

Leucine’s insulin-mediated effects are largely the result of its activation of the classical insulin receptor substrate (IRS)/phosphatidylinositol (PI) 3-kinase (PI3K)/Akt/mTOR signal transduction pathway. In this pathway, the bonding of a substrate (Insulin activates a compound known as PI3K, which in turn activates, Akt. Once phosphorylated and activated, Akt signals the release of the famous mammalian target of rapmycin (mTOR). mTOR then increases the translation of muscle-cell ribosomal proteins that increase ribosome biogenesis, which is the literal production of proteins. Leucine plays a critical role in all of this, creating the translation initiation factors that are the rate-limiting step in the production of the ribosomes spoken about above. Carbohydrates alone, other essential amino acids, and non-essential amino acids have not been shown to have the stimulatory effects on muscle protein synthesis – leucine alone has, highlighting is primacy as a muscle protein activator. Leucine has additionally been shown to positively regulate protein synthesis independent of insulin. In certain trials where rapamycin and leucine were co-administered, rapamycin showed only partial inhibition of leucine’s effects on muscle protein synthesis. Rapamycin is also a critical component to the PI3K/Akt/mTOR pathway, as the mTOR (mammalian target of rapamycin) suggests. One of rapamycin’s primary functions is to inhibit mTOR. So, if leucine-mediate protein synthesis is only partially blocked by rapamycin, but rapamycin fully inhibits mTOR, this suggests that leucine-mediate protein synthesis is only partially dependent on the PI3K pathway. 

Velositol™:

Velositol™, a patented complex of amylopectin/chromium, is a fascinating compound – with emerging clinical data to suggest that it is effective in significantly enhancing skeletal muscle protein synthesis when combined with whey protein (vs whey alone).

In a double-blind crossover study, featuring 10 exercise-trained adults, researchers combined Velositol™ with 6g of whey protein to measure what effects, if any, the compound would exert on skeletal muscle protein synthesis. (The control group consumed 6g of whey alone.) After collecting baseline muscle biopsies – to measure phenylalanine, a marker of muscle-building – the subjects performed eight reps of leg extensions. A final muscle biopsy was taken post-workout, to measure the changes in muscle protein synthesis between the study and control group.

The results were significant: the researchers found that muscle protein synthesis had nearly doubled in the Velositol™ group, compared to the control. The researchers hypothesized that the mechanism of action of Velositol is the stimulated uptake of leucine and other amino acids due to an influx of insulin (from the chromium).

While further study is warranted, the existing data on Velositol™ suggests it’s a must-have addition to any recovery matrix.

References:

For references, see below file;

Core Nutritionals: PWO References

Description:

Core ABC is the athlete’s BCAA.

The most effective, scientifically-established ratio of BCAAs because we know it’s the difference between your first mile and your last. Include clinically-verified servings of beta-alanine, citrulline malate, and glutamine because we know your last rep depends on it.

• 2 scoops per serving.
• 50 servings per container.
• Comprehensive recovery blend.

Rep by rep. Mile by mile. Breath by breath. Every muscle screams at you with pleas of mercy; every bone aches to its core from the pressure. Yet, you still don’t quit – you push on. By hook, or by crook, you will make it. You will succeed. You will win. 
You see, you’re an athlete. You are someone defined to your core by the competitive drive to better yourself at all costs. You need neither trophies, nor accolades; neither cheers, nor recognition. You pay the sweat price for every gain marked in your battle-worn ledger, detailing the struggle your body has endured.

You’re an athlete, and so are we. We don’t make Core ABC for everyone, we make it for you and us. We use the most effective, scientifically-established ratio of BCAAs because we know it’s the difference between your first mile and your last. We include clinically-verified servings of beta-alanine, citrulline malate, and glutamine because we know your last rep depends on it. We know this because we know you, and we know ourselves.

Core ABC is the athlete’s BCAA. It was formulated by athletes, for athletes, for the needs only an athlete can understand. If you can’t say the same about your BCAA, then it may be time for a switch.

Ingredients:

Amino Acids:

If one were to think of the body as a construction project, amino acids would be the most basic building materials: raw lumber, mortar, bricks, and so on. While the assembly of these building blocks is of course critically important to the function of the building – and one of the amino acids, leucine, controls its own assembly – the quality and availability of the materials themselves is arguably more important. Not enough concrete? The foundation cracks and the building falls.

Your body is the exact same way. It is comprised of various amino acids, both essential and non-essential, that comprise the cellular basis of each and every cell in your body. When it comes down to skeletal muscle, the three most important are known as the BCAAs – or branch chained amino acids. Comprised of leucine, isoleucine, and valine, these three little amino acids effectively control the rate at which your muscle grows (hypertrophies), its contractile force, its endurance, and so on – to say they are massively important is an understatement. For this reason, they form the basis of any competently-designed supplement protocol.

Collectively, as stated above, the branch-chained amino acids leucine, isoleucine, and valine are famous for their role in skeletal muscle protein synthesis and metabolism, and additionally comprise approximately one-third of all skeletal muscle protein. Of the three, leucine is both the most physiologically important with respect to muscle mass, and the most extensively studied. Data on leucine demonstrate this amino acid plays critical roles in stimulating skeletal muscle protein synthesis, and ribosomal biogenesis and assembly (the literal building of muscle tissue), along with playing a lesser role in insulin signaling and gluconeogenic processes. As a result of these diverse roles, leucine has been demonstrated to significantly stimulate skeletal muscle protein synthesis, and attenuate protein degradation, by both insulin-mediated and non-insulin mediated mechanisms.

Leucine’s insulin-mediated effects are largely the result of its activation of the classical insulin receptor substrate (IRS)/phosphatidylinositol (PI) 3-kinase (PI3K)/Akt/mTOR signal transduction pathway. In this pathway, the bonding of a substrate (glucose) eventually activates a compound known as Akt. Once phosphorylated and activated, Akt signals the release of the famous mammalian target of rapmycin (mTOR). mTOR then increases the translation of muscle-cell ribosomal proteins that increase ribosome biogenesis, which is the literal production of proteins. Leucine has additionally been shown to positively regulate protein synthesis independent of insulin. In certain trials where rapamycin and leucine were co-administered, rapamycin showed only partial inhibition of leucine’s effects on muscle protein synthesis.

In more practical terms, there is a significant body of evidence demonstrating the positive effect of BCAA’s on athletic performance. Extensive studies in exercise-trained populations reveal that, collectively, BCAA’s may:

• Reduce total muscle soreness after intense resistance training, and/or further delay its onset.
• Decrease muscle recovery time between bouts of intense resistance exercise training.
• Increase lean body mass when used daily, in conjunction with diet and exercise.

While products with larger BCAA ratios (ratio of leucine, to isoleucine, to valine) have recently flooded the market, Core Nutritionals has remained with the gold standard of 2:1:1. This decision is made in recognition of the fact that, for all its potential benefits, there is no evidence demonstrating a realized effect of a larger BCAA ratio – and in fact, all the benefits mentioned above derive from evidence using the gold standard 2:1:1 ratio.

Beta-Alanine:

Carnosine is a bit of an odd duck: we know that it is crucial for muscle function, and that dietary sources of caronsine are essential, but we don’t know precisely how its working. Moreover, for decades, we had no idea how to increase intramuscular concentrations, as exogenous carnosine sources degraded in the body so fast as to be effectively useless.

Enter beta-alanine. Simply a different iteration of one of the amino acids that comprises carnosine itself (alanine), beta-alanine has proven to be the most effective means of significantly increasing intramuscular concentrations of carnosine – and therefore of promoting all of carnosine’s various beneficial effects on muscle performance. If that weren’t enough, beta-alanine has also demonstrated beneficial physiological effects independent of its parent compound. In order to understand why, though, we need to first understand some of the basic behind carnosine itself.

Carnosine, a cytoplasmic dipeptide synthesized from the precursors L-histidine and l-alanine, is present in high concentrations in skeletal muscle and plays a pivotal role as a, “chemical buffer” in myocytes (muscle cells). It has long been known that carnosine concentrations are highest in glycolytic, rather than oxidative muscle fibers (roughly speaking, explosive vs., endurance muscle fibers, respectively), and thus long hypothesized that this amino acid is required for sustained performance during supramaximal exercise. Recent research demonstrates that carnosine exerts its physiological effects in long hypoxic (low oxygen) drives by functioning as a high-capacity pH buffer in skeletal muscle, preventing the pH ratio of plasma from dropping too low – and therefore preventing crucial pH-dependent processes such as protein synthesis from being inhibited by acidosis.

Despite its critical role in skeletal muscle anaerobic performance, intramyocellular synthesis of carnosine is rate-limited by the availability of l-alanine. Unfortunately, the majority of literature demonstrates that attempting to increase intramuscular levels of carnosine via either direct carnosine or alanine supplementation is largely ineffective due to carnosine/alanine pharmacokinetics. Enter beta-alanine. Research with beta-alanine demonstrates consistent and dose-dependent increases to intramuscular carnosine concentrations with beta-alanine supplementation, with certain studies showing an increase of 40-60% with chronic administration. These same literature reveal a synergistic effect of exercise on beta-alanine supplementation, whereby the muscle adaptive changes associated with resistance training promote further intramuscular carnosine production in response to beta-alanine supplementation.

In simpler language, this essentially means that beta-alanine is a dietary supplement that promotes its own effects in combination with exercise. As you exercise, you simultaneously intensify beta-alanine’s physiological actions – both directly, as well as in the production of intramuscular carnosine. Once ingested, beta-alanine’s exercise-specific beneficial activity is well-established. Elevation of intramuscular caronsine content via beta-alanine supplementation has been show to improve performance in the following ways:

• Both acute and chronic increases in total work capacity, measured by total volume during exercise sessions.
• Highly significant increases to TTE (total time to exhaustion), one of the most accurate and comprehensive measures of endurance. In various trials, beta-alanine supplementation has been shown to increase TTE by upwards of 20%.
• Increases to total muscle power output in both acute and chronic trials, suggesting that beta-alanine’s most significant benefit is to those engaging in power-dependent resistance training.

In total, a significant body of research exists to suggest that beta-alanine may significantly increase muscle power output, strength, training volume and output, overall performance in hypoxic (oxygen-deprived) conditions and peak VO2 max (oxygen holding capacity).

These myriad benefits make beta-alanine both one of the most-studied, and most well-rounded dietary supplements. Beta-alanine not only has direct, actionable physiological effects, but also promotes critical muscle physiologic adaptations that promote its own effects.

Citrulline Malate:

Citrulline is a non-essential, non-protein amino acid heavily involved in the urea cycle. Citrulline is also a critical source of endogenous (natural) arginine, as it is rapidly and efficiently converted to arginine in the vascular endothelium and other tissues. Arginine, in turn, is used as the substrate by NOS (nitric oxide synthase) to produce NO, more commonly known as nitric oxide.

Citrulline’s benefits have been shown to be greater than its parent compound. While arginine undergoes direct hepatic (liver) metabolism through the enzyme arginase, citrulline bypasses hepatic metabolism entirely and it is delivered straight to the bloodstream. The result is that gut absorption and plasma (blood) bioavailability studies comparing citrulline and arginine have shown two things. First, that citrulline is less readily destroyed and has greater absorption than arginine. Second, that citrulline supplementation increases arginine levels more effectively than arginine supplementation itself.

This translates to promising results. For example, animal studies show a significant increase in anaerobic performance at a 250mg/kg/day serving of citrulline, while studies in humans implicate citrulline in both aerobic and anaerobic performance increases. As a critical part of the urea cycle, citrulline’s performance benefits are thought to be a result of its role in ammonia clearance. Citrulline is implicated in reducing the oxygen cost of muscle processes, along with increasing the rate of post-exercise ATP and phosphocreatine replenishment. As ATP and phosphocreatine are the body’s ‘exercise fuel,’ this may result in citrulline delaying time to exhaustion in aerobic and anaerobic exercise.

Glutamine:

Prior to discussing the physiological effects of glutamine – and more specifically, whether or not it poses any tangible benefits to the proliferation of skeletal muscle tissue – we need to discuss its place in supplementation, in general. Glutamine is perhaps the most lamented of all the amino acids, regularly denigrated to the point that it’s a joke to many athletes. This is largely a problem of perception: glutamine is not, specifically speaking, an anabolic amino acid, and therefore is of little use as it pertains to, “building tissue.” But, “building tissue” is not the only purpose a supplement may have, and the corollary, preserving tissue (or anti-catabolism) is arguably as important. It is in this capacity that glutamine shines, and for this reason it is included in Core ABC.

The literature in this context is encouraging. Various studies demonstrate that glutamine supplementation may suppress or inhibit the action of enzymes known as proteases, responsible for the hydrolytic breakdown of protein and amino acids into smaller compounds. These studies show both site-specific and whole-body reductions in this process known as, “proteolysis” in the later stages of skeletal muscle recovery. While encouraging, these data are perhaps not as promising as glutamine’s more indirect effects on the catabolic process – namely its effect on glucose metabolism. In both in vitro and in vivo trials, glutamine has shown the ability to promote the synthesis and storage of glycogen (glycogenesis), both in concert with an independent of carbohydrate ingestion.

These effects are most pronounced in physiologic situations where carbohydrate metabolism reliant on insulin signaling are compromised – such as the chronic caloric deficits present in a dieting situation. In this context, glutamine may function as a critical addition, potentiating the body’s glycogen synthesis and storage response; maximizing the limited amount of carbohydrates a dieter may be ingesting.

References:

1: Valerio, A., D’antona, G., et al. BCAAs, Mitochondrial Biogenesis, and Healthspan: An Evolutionary Perspective. Aging. May 2011. 3(5), 464-470.

2: Bajotto, G., Sato, Y., et al. Effect of BCAA Supplementation During Unloading on Regulatory Components of Protein Synthesis in Atrophied Soleus Muscles. European Journal of Applied Physiology. 2011. 111, 1815-1828.

3: Borgenvik, M., Nordin, M., et al. Alterations in Amino Acid Concentrations in the Plasma and Muscle in Human Subjects during 24 Hour of Simulated Adventure Racing. European Journal of Applied Physiology. 2012. Published Ahead of Print.

4: a Luz, Claudia, Nicastro, H., et al. Potential Therapeutic Effects of BCAA Supplementation on Resistance Exercise-Based Muscle Damage in Humans. Journal of the International Society of Sports Nutrition. 2011. 8(23).

5: Dualano, A, et al. Branched-Chain Amino Acids Supplementation Enhances Exercise Capacity and Lipid Oxidation During Endurance Exercise After Muscle Glycogen Depletion. Journal of Sports Medicine and Physical Fitness. 2011.51(5), 82-88.

6: Hsu, M., Chien, K., et al. Effects of BCAA, Arginine, and Carbohydrate Combined Drink on Post-Exercise Biochemical Response and Psychological Condition. Chinese Journal of Physiology. April 2011. 542), 71- 78.

7: Glynn, E., Fry, C., Drummond, M., Timmerman, K., Dhanani, S., Volpi, E., Rasmussen, B. Excess Leucine Intake Enhances Muscle Anabolic Signaling but Not Net Protein Anabolism in Young Men and Women. The Journal of Nutrition. 2010. 140(11), 1970-1976.

8: Sharp, C., Pearson, D. Amino Acid Supplements and Recovery from High-Intensity Resistance Training. Journal of Strength and Conditioning Research. 2010. 24(4), 1125-1130.

9: Ipoglou, T., King, R., Polman, R., Zanker, C. Daily L-Leucine Supplementation in Novice Trainees During a 12-Week Weight Training Program. International Journal of Sports Physiology and Performance. 2011. 6(1), 38-80.

10: Jourdan, C., et al. Body Fat Free Mass is Associated with the Serum Metabolite Profile in A Population Based Study. PLOS One. 2012. 7(6), e40009.

See more references at below link,

Core-ABC-Product-References.pdf

Description:

The body requires a tremendous amount of energy during a rigorous weight training session and also needs the strength to recover, restore, and rebuild after a thorough workout session. The body produces this energy through the metabolism of the dietary intake throughout the day. The body nutrients are primarily comprised of Proteins, Fats, and Carbohydrates. These macronutrients are synthesized during metabolism to generate the energy required by the body to build new muscle tissues, repair and retain the old ones. They are also responsible for the energy levels during the weight training sessions. Anyone who is into progressive severe weight training will agree that the energy levels during and after workout determine the effectiveness of the workout sessions. A course that drains the energy entirely might result in cutting down on the workout session, which might cause fatigue and burn those hard-earned muscles instead of building them.

Carbohydrates are the natural energy source of the body. The body in the absence of Carbs burns the Protein, which might be harmful during the long run, as in lack of excess Protein to consume during and after a workout session, the body will end up burning the muscles, which will prove costly. Thus, to be safe, the right amount of Carbs can be added as pre, post, and even during the workout sessions. This will ensure that the muscle retains Protein, and the body gets supplied with its preferred choice of energy source.

Ingredients:

Homopolysaccharide derived from potato, rice, and corn: It is a complex Carbohydrate consisting of identical monomers. It is the most abundant form of Carbohydrate complex that provides the body with a constant energy supply for a sustained period. It is easily absorbed by the body and ensures instant production of energy by breaking down into Glycogen during metabolism. Carbohydrates being the natural preferred energy source of the body is instantly utilized by the body while strenuous physical activity to generate energy. The natural absorption and assimilation of Homopolysaccharide derived from potato, rice, and corn ensure that it can be used as an energy source. Due to the complex structure of the Carb, the typical spike and fall of energy levels that affect the blood components are absent, making it ideal to be used as a high-performance supplement. It ensures a longer duration of the weight training sessions and faster recovery without fatigue.

It also contains artificial flavors, artificial color (red 40, yellow 6), and Sucralose.

FAQs

Q. Can it be used as a pre-workout supplement?

A. It is a great pre-workout supplement and can also be used as a post-workout supplement for fast recovery.

Q: Can it be stacked with other supplements?

A. YES

Q: How to use it? 

A: A single scoop can be used with 8-10 oz of water, half an hour before or after training sessions.

References: 

1. Philip E Apong. Nutrition and Dietary Recommendations for Bodybuilders. Nutrition and enhanced sports performance, 737-750, 2019

2. Eric R Helms, Alan A Aragon, Peter J Fitschen. Evidence-based recommendations for natural bodybuilding contest preparation: nutrition and supplementation. Journal of the international society of sports nutrition 11 (1), 20, 2014

3. Melinda M Manore, Janice Thompson, Marcy Russo. Diet and exercise strategies of a world-class bodybuilder. International Journal of Sports Nutrition and Exercise Metabolism 3 (1), 76-86, 1993

4. Suzanne Nelson Steen. Precontest strategies of a male bodybuilder. International Journal of Sports Nutrition and Exercise Metabolism 1 (1), 69-78, 1991

5. Laura J Morrison, Frances Gizis, Barbara Shorter. Prevalent use of dietary supplements among people who exercise at a commercial gym. International journal of sports nutrition and exercise metabolism 14 (4), 481-492, 2004

6. Susan M Kleiner, Terry L Bazzarre, Barbara E Ainsworth. Nutritional status of nationally ranked elite bodybuilders. International Journal of Sports Nutrition and Exercise Metabolism 4 (1), 54-69, 1994