An active metabolism begins with proper thyroid function and is enhanced with adrenal stimulation. The most renowned thyroid agonists are T3 and T4, which are then able to activate multiple mechanisms of fat loss. In addition, adrenal stimulants drive even greater boosts to metabolic rate for extreme body fat loss.
3,5 and 3,3 isomers of Diiodo L-Thyronine mimic thyroid activity for fully-encompassed fat loss.
Caffeine boosts energy and increases metabolic rate
2-Aminoisoheptane acts similarly to DMAA for intense thermogenesis
With T2 Rise, reductions in body fat are imminent. T2 hormone-mimetics activate all natural mechanisms of fat loss – including body fat lipolysis, oxidation, and disposal. Simultaneously, caffeine and 2-Amino boost mood.
2-Aminoisoheptane (aka, dimethylhexylamine, or just “2-amino”) is a stimulant structurally similar to dimethylamylamine (DMAA).
May enhance mood and feelings of euphoria
May assist in fat burning and body leaning
May improve focus
Caffeine is the most ubiquitous supplement in modern society; known for its ability to enhance wakefulness and energy
Caffeine works by stimulating the adrenal glands and releasing adrenaline
This enhances pain tolerance, which is the primary mechanism by which caffeine enhances endurance performance.
Caffeine may also enhance the mind-muscle connection by improving attention and cognition
Theanine is a non-proteogenic amino acid that promotes relaxation and mood.
Combining theanine with caffeine takes the “edge” off of caffeine
Theanine smooths the anxiety and irritability that can be associated with caffeine
This enhances focus and attention
Naringin is a bioactive polyphenol common in grapefruit and orange peel.
Naringin activates AMPK (adenosine monophosphate kinase) to increase thermogenesis
Supplementing naringin has been shown to promote weight loss
3,5 & 3,3 Diiodo L-Thyronine
These two thyroid mimetics are also known as T2.
T2 is a less potent version of the T3 thyroid hormone.
T2 enhances multiple avenues of fat loss
This includes enhanced mitochondrial function, body fat reduction, lipid metabolism, and insulin sensitivity
Q: What is the best way to use T2 Rise?
A: As a dietary supplement, take 1 serving (1 capsule) once per day.
Q: Can I stack other products with T2 Rise?
A: Yes. For a low-impact recovery product, stack T2 Rise with Rehab.
Wang, M., Haider, S., Chittiboyina, A. G., Parcher, J. F., & Khan, I. A. (2018). 1, 5-Dimethylhexylamine (octodrine) in sports and weight loss supplements: Natural constituent or synthetic chemical?. Journal of pharmaceutical and biomedical analysis, 152, 298-305.
Catalani, V., Prilutskaya, M., Al-Imam, A., Marrinan, S., Elgharably, Y., Zloh, M., ... & Corazza, O. (2018). Octodrine: new questions and challenges in sport supplements. Brain sciences, 8(2), 34.
Paton, C. D., Lowe, T., & Irvine, A. (2010). Caffeinated chewing gum increases repeated sprint performance and augments increases in testosterone in competitive cyclists. European journal of applied physiology, 110(6), 1243-1250.
Carr, A. J., Gore, C. J., & Dawson, B. (2011). Induced alkalosis and caffeine supplementation: effects on 2,000-m rowing performance. International journal of sport nutrition and exercise metabolism, 21(5), 357-364.
Astorino, T. A., Terzi, M. N., Roberson, D. W., & Burnett, T. R. (2010). Effect of two doses of caffeine on muscular function during isokinetic exercise. Medicine and science in sports and exercise, 42(12), 2205-2210.
Keijzers, G. B., De Galan, B. E., Tack, C. J., & Smits, P. (2002). Caffeine can decrease insulin sensitivity in humans. Diabetes care, 25(2), 364-369.
Ganio, M. S., Johnson, E. C., Klau, J. F., Anderson, J. M., Casa, D. J., Maresh, C. M., ... & Armstrong, L. E. (2011). Effect of ambient temperature on caffeine ergogenicity during endurance exercise. European journal of applied physiology, 111(6), 1135-1146.
Lu, K., Gray, M. A., Oliver, C., Liley, D. T., Harrison, B. J., Bartholomeusz, C. F., ... & Nathan, P. J. (2004). The acute effects of L‐theanine in comparison with alprazolam on anticipatory anxiety in humans. Human Psychopharmacology: Clinical and Experimental, 19(7), 457-465.
Ritsner, M. S., Miodownik, C., Ratner, Y., Shleifer, T., Mar, M., Pintov, L., & Lerner, V. (2011). L-theanine relieves positive, activation, and anxiety symptoms in patients with schizophrenia and schizoaffective disorder: an 8-week, randomized, double-blind, placebo-controlled, 2-center study. Journal of Clinical Psychiatry, 72(1), 34.
Higashiyama, A., Htay, H. H., Ozeki, M., Juneja, L. R., & Kapoor, M. P. (2011). Effects of L-theanine on attention and reaction time response. Journal of Functional Foods, 3(3), 171-178.
Owen, G. N., Parnell, H., De Bruin, E. A., & Rycroft, J. A. (2008). The combined effects of L-theanine and caffeine on cognitive performance and mood. Nutritional neuroscience, 11(4), 193-198.
Zygmunt, K., Faubert, B., MacNeil, J., & Tsiani, E. (2010). Naringenin, a citrus flavonoid, increases muscle cell glucose uptake via AMPK. Biochemical and biophysical research communications, 398(2), 178-183.
Murase, T., Misawa, K., Haramizu, S., Minegishi, Y., & Hase, T. (2010). Nootkatone, a characteristic constituent of grapefruit, stimulates energy metabolism and prevents diet-induced obesity by activating AMPK. American Journal of Physiology-Heart and Circulatory Physiology.
Dow, C. A., Going, S. B., Chow, H. H. S., Patil, B. S., & Thomson, C. A. (2012). The effects of daily consumption of grapefruit on body weight, lipids, and blood pressure in healthy, overweight adults. Metabolism, 61(7), 1026-1035.
Hernandez, A. (2015). 3, 5-diiodo-L-thyronine (t2) in dietary supplements: what are the physiological effects?.
Horst, C., Rokos, H., & Seitz, H. J. (1989). Rapid stimulation of hepatic oxygen consumption by 3, 5-di-iodo-L-thyronine. Biochemical Journal, 261(3), 945-950.
Lanni, A., Moreno, M., Cioffi, M., & Goglia, F. (1992). Effect of 3, 3′-diiodothyronine and 3, 5-diiodothyronine on rat liver oxidative capacity. Molecular and cellular endocrinology, 86(3), 143-148.
The T2 Rise Fat Burner Capsules was built with people like you in mind. Something to keep you happy. Every. Single. Day.
BURNING FAT WHILE NOT LOSING MUSCLE IS NOT A SKILL, BUT AN ART.
It’s something which 19X Olympia Champion Coach, The Pro Creator® Hany Rambod has demonstrated countless times by shaping the most insane physiques the world has ever seen.
The goal which so many athletes have trouble achieving is finding the correct balance between increasing metabolic rate and controlling appetite enough to preserve muscle mass while blasting away fat away. There’s a reason why multiple physique champions trusts Hany, and it’s because he understands this balance.
It’s this keen understanding of physique remodeling that has lead to the evolution of one of Hany’s best kept secrets, Lipocide, and now Lipocide IR (Instant Release) powder. This real-world tested formulation has been his “go-to” tool to get the best in world shredded and dialed in. By curbing appetite, accelerating your metabolism, and pushing mental drive for hours, Lipocide IR is part of a complete weight loss solution.
This formulation came from years of finding the right balance of what works on paper in clinical studies and what works in real-life testing. Hany created a balanced formula that would give you that clean energy feel without feeling lethargic. Contrary to popular belief, the goal should not be to look to crush someone’s appetite, but rather curb it so they can eat less and have fewer cravings. If you kill a person’s appetite to the point where they don’t eat, potentially they will lose muscle from the lack of calories and protein. Hany specifically designed Lipocide IR to help control the consumer’s appetite by reducing their cravings, and to burn more calories while doing cardio.
Here’s a closer look at the Pro Creator’s answer to creating that balance between a shredded physique while minimizing muscle loss.†*
Cocoa Extract (as Chocamine®) –Over the years many synthetic stimulants have been removed from the market place. However, despite this Evogen has been able to stay ahead of the curve by using powerful natural extracts that contain many thermogenic amines and methylxanthine alkaloids. These key components accelerate thermogenesis and make cardio a breeze.†*
Acetyl L-Carnitine –The acetylated form of L-Carnitine is known for its great bio-availability and purported nootropic ef-fects.* Moreover, carnitine helps transport lipids into the mitochondrial matrix with the CPT-1 system to create cellular energy. Without this, the body cannot metabolize fat efficiently for thermogen-esis.†*
Choline Bitartrate –This bioavailable form of choline has demonstrated in research to support mood states. Its secondary use is a lipotropic agent having the ability to promote lipid oxidation.†*
Citrus Aurantium Extract Advantra-Z –Evogen Nutrition uses the patented and clinically studied variant of citrus aurantium extract called Advantra-Z. This powerful extract has stimulant properties which interact with the adrenergic receptor system through a high p-synephrine content. It has a wealth of supporting research which has demonstrated that it has an exceptional effect on the body.†*
Green Coffee Bean Extract –This powerful ingredient has received critical acclaim because of its ability to increase thermogenesis and anti-oxidant activity.
L-Tyrosine –Tyrosine is a powerful nootropic that compliments stimulants to support cognitive tasks that require focus.* Alone it is able to do so under stressful conditions suggested by clinical research.†*
Caffeine Anhydrous -Caffeine has been shown to enhance energy and thermogenesis. It is the backbone of many formulations, and Evogen Nutrition is not afraid to show you just how much is in the product.†*
Caspisum Annum Extract –If you’ve ever had a red pepper then you know it produces heat, but the concentrated extract actually stimulates catecholamines such as epinephrine and norepinephrine. These powerful molecules help stimulate the central nervous system and lipolytic processes.†*
Piper Nigrum Extract (as BioPerine) –This advanced bioavailability enhancer is standardized for a component called piperine. This innovative compound enhances bioavailability of many ingredients found in supplements by interacting with the intestinal brush border and stimulating digestive enzymes. In many animal models piperine has demonstrated its effectiveness on numerous ingredients.†*
Toothed Clubmoss Extract –This ancient extract contains bioactive components such as huperzine A that have shown to have a profound nootropic effect. It’s acetylcholinesterase inhibition allows for other ingredients such as choline bitartrate to have a more pronounced effect due to inhibitory effect on choline metabolism.
THERE YOU HAVE IT. A RECIPE FOR SHREDDED SUCCESS THAT WON’T BREAK YOUR BUDGET IN AN ALL NEW INSTANT RELEASE POWDER FORM.
Lucky for you, Hany has finally yielded to the demands of the dedicated customers of Evogen Nutrition and released his Pro Creator quality tool to get you shredded. It’s up to you to take the next step towards the all new metabolic accelerator that Team Evogen has proudly embraced and has helped Hany achieve 19 Olympia titles.†*
This product is only intended to be consumed by healthy adults, 18 years of age or older. Do not use this product if you are pregnant, expect to become pregnant, or are nursing. Always consult with your physician before using this or any other dietary supplement product. Do not use this product without consulting your physician if you are using any prescription or over the counter medication or if you have any pre-existing medical condition. Immediately discontinue use and consult your physician if you experience any adverse reaction to this product. Do not use if safety seal is broken or missing. Store in cool, dry place away from moisture and sunlight.
KEEP OUT OF REACH OF CHILDREN
* These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
† When combined with a proper exercise and nutrition program. Please consult with your physician before using this or any other dietary supplement product.
Life is too short to live without the Evogen : LIPOCIDE IR 30 SERV. Be happy. Be Content. Be Satisfied.
Inventory Last Updated: Jul 07, 2020
Core Nutritionals : Burn Ultra
Core Nutritionals’ Core BURN Ultra powder is that better way. There are no gimmicks here, no tricks and trade secrets. Just the very best, most verified-effective ingredients at serving sizes known to exert powerful effects on the human body. With Core BURN Ultra, we have taken many of the same ultra-potent ingredients found in Core BURN, mixed in a few amazing new friends, and put the whole thing in a delicious, convenient, and rapidly-dissolving powder. In the end, it’s your choice: flashy magazine ads, or an unrivaled and extreme thermo that plain, flat-out works as promised. If we had to choose between a slim wallet or a slim waist, we’d choose the latter – because we’d choose Core BURN Ultra.
Highlighted Ingredients of Core Burn Ultra:
Garcinia Cambogia Fruit Extract
Green Coffee Extract
Coleus Forskohlii Root Extract
Advantra-Z Orange Extract
To assess tolerance, mix 1 scoop with 8-12 oz of water and consume first thing in the morning. Am additional 1 scoop can be taken 5-6 hours later. Once tolerance is assessed, serving can be increased to 1 scoop before breakfast, 1 scoop after breakfast, and 1 scoop 5-6 hours later. Do not exceed 3 scoops in a 24 hour period. Do not use longer than 8 continuous weeks without a 4 week break.
On the fence about this Core Nutritionals : Burn Ultra? Don't be. Let our satisfaction guarantee address your concerns.
Inventory Last Updated: Jul 07, 2020
L-Carnitine 31 Serv
SUPPORTS FAT BURNING*
PROVIDES NATURAL ENERGY*
ZERO SUGAR, CALORIES & CARBS
WHAT IS L-CARNITINE?
L-CARNITINE is a liquid based stimulant free supplement typically used to help promote muscular energy and fat burning.* L-Carnitine is an amino acid that helps convert fatty acids to be used as a fuel source (which promotes muscular energy).* This process not only promotes muscular energy but also fat loss and lean muscle growth.* L-Carnitine is stimulant free and perfect to stack alongside a stimulant fat burner and other weight management products to enhance results.*
Delicious flavors – L-Carnitine Liquid isn’t just another liquid carnitine on the market in boring Fruit Punch and Vanilla… we took these flavors to the next level in typical MAN Sports fashion! You gotta enjoy what you’re drinking daily if you want to stick to your supplement regimen and get results! Try all 4 incredible flavors – Rainbow Sherbet, Glacier Blue Razz, Lemondrop and Mango!
Q: What is L-Carnitine and what does it do? A: L-Carnitine is an amino acid that is typically used to help promote muscular energy and fat burning as it converts fatty acids to be used as a fuel source.*
Q: Is L-Carnitine a stimulant? A: No, L-Carnitine is a stimulant free supplement. This makes L-Carnitine an ideal product to stack alongside a stimulant fat burner like our product Scorch!
Q: How do I take Liquid L-Carnitine? A: You can simply take it by itself (a quick shot) or mix it in with your favorite beverage or juice.
The L-Carnitine 31 Serv is far and away, one of our most popular items. People can't seem to get enough of it.
Inventory Last Updated: Jul 07, 2020
Core Nutritionals : Burn
Drop the kitchen sink approach and get surgical.
Core BURN is formulated with a diverse range of proven ingredients to create a powerful, balanced, and effective product. Core BURN is designed to target precise primary and secondary metabolic pathways, at multiple targets, to ensure maximum weight management.
2-3 capsules per serving.
75-50 servings per container.
Jitter-free weight management.
Every week, there is a new story about a “breakthrough” or “miracle” substance that will make every other ingredient before it obsolete. Some of these claims may have merit, but the truth is that the biochemical processes of lipolysis are very complex and tightly regulated by the endocrine system and other biochemical pathways. Navigating this maze to effectively manage weight and body composition therefore requires more than a single, “miracle” compound: it involves numerous agents that together activate certain metabolic functions, while suppressing others. No single, “magic” compound does the job alone.
Core BURN is formulated to drop the kitchen sink and “miracle” ingredient tactics, and instead uses a diverse range of proven ingredients to create a powerful, balanced, and effective product. Core BURN is designed to target precise primary and secondary metabolic pathways, at multiple targets, to ensure maximum effectiveness. No more playing darts in the dark when it comes to weight management categories; randomly including ingredients, in whatever servings, hoping that something works. Specific. Multi-targeted. These words exemplify the new approach: amazing ingredients, in clinically-reflected serving sizes, all included in a non-proprietary blend so you know exactly what you’re consuming.
L-carnitine is a derivative of the amino acid lysine and, as certain conditions outpace the body’s ability to produce it, l-carnitine is considered a conditionally essential amino acid. While endogenous biosynthesis of l-carnitine from the amino acids lysine and methionine is sufficient for essential processes – along with dietary sources of carnitine from protein-rich red meat, for example – dietary supplementation of carnitine may pose benefits in certain physiological conditions.
Unfortunately, due to excess metabolism of l-carnitine by microorganisms in the small intestine, exogenous supplementation with oral l-carnitine has proved ineffective. ALCAR, an acetylated version of l-carnitine, has considerably higher oral bioavailability, due likely to only partial hydrolytic metabolism. Once in the bloodstream, ALCAR plays a fundamental role in the production of energy, acting as the catalyst for the beta-oxidation of long chain fatty acids by the mitochondria; regulating the CoA to Acyl-CoA ratio (necessary for the production of ATP); and the metabolism of carbohydrates. ALCAR also is an excitatory agent for neurons, increases neuronal transmission, and increases the production of neurotransmitters and neurohormones such as dopamine and serotonin.
Green Tea Extract (Camilla sinensis) (leaf) (50% EGCG):
Along with caffeine from the coffee plant, EGCG (Epigallocatechin gallate) from various sub-species ofCamilla sinesis(green tea) is perhaps the most widely known and reputable anti-lipogenic and lipolytic agent in the world. Both compounds have well established anti-obesity effects, detailed in a deep body of literature featuring in vitro cell culture, as well as in vivo animal and human trials.
In animal and human studies, green tea generally and EGCG more specifically has been demonstrated to reduce the absorption of dietary lipids and modulate their subsequent metabolism, increase glucose utilization in resting states, as well as initiate de novo lipogenesis in both maximal and submaximal exercise states.
A two month dietary intervention, for example, showed that the daily consumption of a catechin-rich tea – EGCG is the most well-known of the catechins – by healthy humans led to a reduction of bodyweight of up to 20%, the consequence of increased lipolysis (as measured by FFA urinary clearance). A separate double-blind, placebo controlled trial using EGCG consumption both with, and without caffeine, demonstrated the increased oxidation of fatty acids within two hours of a meal – at level increases of 49% and 35%, respectively.
These studies suggest that EGCG not only exerts an inhibitory effect on the accumulation of lipids, but that it perhaps actively leads to the hydrolyzation of triglycerides for use as energy in the form of FFAs. In particular, this effect seems to be potentiated in the presence of caffeine ingestion, suggesting a synergistic effect between EGCG and caffeine on the hydrolyzation and subsequent oxidation of triglyceride stores.
Green Coffee Extract (Coffee arabica) (bean) (50% chlorogenic acid):
Chlorogenic acids (CGAs) are phenolic compounds created during the metabolism of various isoquinic acids found in the leaves of both coffee and tea. In addition to the well-established sympathomimetic effects of coffee and tea’s constituents, recent research has demonstrated a range of other potential benefits for compounds such as chlorogenic acids.
Recent literature suggests that the consumption of both green coffee, as well as standardized extracts of CGAs, relax the vasculature and improve vasoreactivity, impose an inhibitory effect on lipid accumulation and body weight in both mice and humans, and modulate glucose metabolism via the glucose-6-phosphate pathway.
Trials in both humans and mice using 1% extracts of green coffee bean revealed significant bodyweight reductions over periods of two and eight weeks. Researchers hypothesized that the bodyweight reductions associated with oral CGA administration was associated with the products numerous mechanisms of action, rather than a single, isolated cause.
Olea europaea, more commonly known as the olive, is a species of a small tree in the family Oleaceae, native to the coastal areas of southeastern Europe, western Asia and northern Africa, as well as northern Iran at the south end of the Caspian Sea.
As the fruits, oils, and extracts of Olea europaea L. are a dietary component for a significant portion of the world’s population, the plant has become associated with a wide-range of physiologic and metabolic benefits. These properties are largely attributed to the phenolic compounds of olive leaves, including: caffeic acid, verbascoside, oleuropein, luteolin 7-O-glucoside, rutin, apigenin 7-Oglucoside, and luteolin 4′-O-glucoside. Collectively, these olive polyphenols are responsible for a wide-range of postulated health benefits.
Oleuropein, in particular, is purported to have several pharmacological properties including antioxidant, anti-inflammatory, anti-atherogenic, and anti-microbial effects. Recent research in animals has also demonstrated that oleuropein may potentiate the response of 5'-deiodinase, the enzyme responsible for the irreversible conversion of thyroxine (T4) into triiodothyronine (T3), the active thyroid hormone.
Caffeine (1,3,7-trimethylxanthine) and Theomobrine (3,7-dimethyl-1H-purine-2,6-dione):
Caffeine is the most widely consumed, and perhaps one of the most reviewed, psychoactive compounds. Its physiological effects in a range of areas have been well-documented, including exercise performance, information processing, alertness and mood enhancement, attention, and awareness, along with its anti-lipogenic and lipolytic abilities. Caffeine is also the most well-known in the methylxanthine compound class, the constituents of which inter-metabolize into one another in the human body and largely share similar effects.
Various clinical trials have demonstrated that xanthines – including caffeine and theobromine – exert potent lipolytic (the breakdown of triglycerides into fatty acids) and oxidative actions as sympathomimetic amines. In less scientifically-complex parlance, this means caffeine is forcing your body to preferentially use adipose tissue as a fuel source for the oxidative provision of ATP (your body’s energy currency).
Evidence for xanthine’s capacity as lipolytic agents is widely available. In a clinical study featuring four separate trials in both normal and obese subjects, for example, caffeine was found to significantly increase fatty acid metabolism (as measured by serum fatty acid concentration), resting metabolic rate, and total fat oxidation – suggesting the preferential substrate selection spoken about above occurs in both normal and obese individuals. Other trials have demonstrated the effects of methylxanthines on total fat mass (reduction), lean body mass (increases), stamina and endurance, as well as cardiovascular capacity.
Additionally, as selective cAMP potentiators, through the beta-adrenergic pathway, caffeine and theobromine have been hypothesized to exert a synergistic effect on lipolysis when combined with forskolin.
Bacopa monnieri (BM), also known as the water hyssop commonly, or as Brahmi in Ayurvedic texts, is a small creeping herb endemic to sub-tropical India. The herb has been used in traditional Indian medicine for well over one thousand years, with its first recorded usage coming in the 6thcentury A.D. In this traditional context, BM has been used for a wide-range of purposes, including as a treatment of asthma and epilepsy.
More recently, BM has been the subject of numerous cognition and memory trials, as the plant has a well-established nootropic effect. Likely through modulation of the serotonin reuptake system, clinical trials in healthy human beings have demonstrated that BM possesses a significant effect on the retention of newly-learned information. In several trials utilizing a 300mg daily serving, BM was also shown to decrease the recall delay of newly learned information and reduce short term forgetfulness – suggesting that the herb’s effect on the serotonic and cholinergic systems are increasing the encoding (the literal storing) of memory information.
Beyond cognition and memory encoding, BM has also been demonstrated to function as a potent adaptogen and relaxant – which in the Core BURN formula may help to smooth the effect curve of the product’s stimulants, reducing jitteriness or “crash.”
ForsLean®(Coleus forskohlii) (root) (20% forskolin):Coleus forskohlii is a small perennial endemic to various tropical regions in the world, including South America, sub-Saharan Africa, and India. While the West has recently taken interest in the plant due to the pharmacological properties of its primary bioactive, forskolin, Coleus forskholii preparations and tinctures have been used in both South American and African traditional folk medicinal systems, as well as extensively within Ayurveda.
Due to the ever-increasing interest in the plant’s verifiable pharmacological and physiological effects, however, Coleus forksholii and its extracted constituents have been the subject of numerous animal and human clinical trials in the past decade, primarily in its patented form of ForsLean. These trials have demonstrated the plant to have various effects and applications, including as a lipolytic and anti-lipogenic, and as a powerful antioxidant.
A recent double-blind, randomized, and placebo-controlled human clinical trial featuring obese men found that the daily implementation of ForsLean, for twelve weeks, led to significantly better weight loss outcomes as compared to controls. Overweight men in the ForsLean group experienced not only improved body composition (as measured by total non-lean mass), but also statistically significant increases in lean body mass.
In a separate 8 week trial, in overweight females, ForsLean was found to significantly reduce total bodyweight and significantly increase lean body mass relative to controls. Weight loss was statistically significant after 4 and 8 weeks and the mean amounted to 4.3 and 9.17 lbs respectively.
ForsLean – and more specifically, forskolin – achieves this effect by rapidly, potently, and dose-dependently increasing an important metabolic enzyme known as adenylate cyclase. Adenylate cyclase is an enzyme responsible for catalyzing the formation of cyclic adenosine monophosphate (cAMP) from adenosine triphosphate (ATP). This increase in cAMP formation eventually leads to the activation of an enzyme, protein kinase A, which in turn will phosphorylate and hence activate the enzyme, Hormone Sensitive Lipase (HSL) – the rate-limiting enzyme necessary for stored triglycerides within adipocytes to be released as free fatty acids and utilized for energy.
In more basic terms, this means that forskolin quite literally frees up more fatty acids to be used as fuel for exercise – more or less the perfect scenario in a product such as Core BURN!
Extracts or preparation of Pausinystalia yohimbe, and related sub-species, have been used in traditional and folk medicinal systems such as Ayurveda and Unani for centuries. More recently, the principal bioactive compound in Pausinystalia yohimbe, both as a whole plant, and its extracted components, has been the subject of numerous clinical trials investigating its various physiological pathways.
In particular, recent research has shown that yohimbe bark extracts exert a powerful pre-synaptic inhibiting effect on alpha-adrenergic receptors – making it a potent adrenergic antagonist. This effect seems to be localized and largely specific to adipocytes, attaching to their adrenergic receptor sites and preventing them from receiving the catecholamines (norepinephrine and epinephrine) that would normally initiate growth signals.
While limited, there is some evidence in human, clinical trials to suggest that Yohimbine’s postulated mechanisms of action translate into practical effects. In a placebo-controlled trial involving 20 healthy, lean soccer players, subjects were given 20mg/day in two equal servings, for 21 days. At 21 days, the Yohimbine group reflected small but significant reductions in both total fat mass and bodyfat percentage as compared to controls – at least partially suggesting that Yohimbine may have a plausible role in combination with diet and exercise in weight management.
Synephrine is a naturally-occurring alkaloid with adrenergic agonist activity, structurally related to epinephrine, norepinephrine, ephedrine, and other compounds with a phenethylamine base structure. Despite its chemical similarity to these compounds, synephrine in its various isomers exerts unique effects on adrenergic receptors, in particular, and the human body, in general.
Synephrine exists in three isomer forms: para-, meta- and ortho-synephrine. The molecular changes between the three isoforms are minute, but even this small change results in significant alterations to each isomer’s physiological and pharmacokinetic profile. Two of synephrine’s isomers, both p- and m-synephrine, have been shown to naturally occur in mammals (in low concentrations). As a sympathomimetic, synephrine has been the subject of numerous trials, assessing its effects on weight management, thermogenesis, metabolic rate, and caloric expenditure. In a double-blind, randomized, and placebo-controlled trial involving 10 healthy individuals, the p-synephrine isomer was administered at a 50mg serving, both alone, and in combination with hesperidin and naringin. The authors measured resting metabolic rate (RMR), blood pressure, and heart rate, along with subjective feelings of mood and energy, at baseline, and at 45-mintues and 75-minutes after ingestion. The authors reported a significant increase in RMR in each of the supplement groups, relative to placebo.
In addition to studies on synephrine in its various isomers, Advantra-Z®, the specific form of synephrine utilized in Core BURN, has itself and in combination with other ingredients, been the subject of various clinical trials in humans. In a randomized, double-blind, placebo-controlled trial featuring 70 obese adults, a formulation containing Advantra-Z® was found to significantly reduce fat mass, body weight, and hip and waist girth as compared to controls, while leading to an increase in lean mass. As the authors comment, these results are in-line with a recent systematic review of human clinical studies involving Citrus aurantium, that revealed the ingredient to reliably increase resting metabolic rate up to 7.2%, increase energy expenditure of up to 13.4%, and weight loss of over 2.9 kg, with no serious adverse events in any of the trials.
In addition, the combination of caffeine and synephrine appears to potentiate each ingredient’s effects – with rates of fatty acid liberation, heart rate, metabolic rate, and fatty acid oxidation increased in clinical trials featuring the combination. In the same systematic review mentioned above, the authors note that the combination of synephrine and caffeine led to a small but significant reduction in fat mass of 3lbs, and a reduction in bodyfat of 2.9%.
Combined with not only caffeine, but the other ingredients in Core BURN, Advantra-Z® appears to be a potent weapon in the arsenal for body composition and weight management.
The Core Nutritionals : Burn is the product you didn't think you need, but once you have it, something you won't want to live without.
Inventory Last Updated: Jul 07, 2020
Core Nutritionals : SHRED Pineapple Strawberry
It’s late evening and you need to crush your workout – worst of all, your deep in a diet. You haven’t taken your thermogenic yet, you know you need to, but you also know that downing a few hundred milligrams of stimulants at 8 PM is not conducive to healthy sleep patterns. So, what do you do?
1 scoop per serving.
56 servings per container.
Healthy thyroid support.
It’s late evening and you need to crush your workout – worst of all, your deep in a diet. You haven’t taken your thermogenic yet, you know you need to, but you also know that downing a few hundred milligrams of stimulants at 8 PM is not conducive to healthy sleep patterns. So, what do you do?
Prior to now, you sucked it up and chugged your ultra-potent and effective stimulant-based thermogenic (such as BURN or BURN Ultra!) and dealt with the consequences. But as of now, you take a scoop of the ultra-potent and equally effective, non-stimulant-based thermogenic Core SHRED.
We’ve taken our typical approach to product formulation – proven ingredients at clinically-effective and clinically-proven serving sizes – and applied it to creating a comprehensive, multiple-pathway non-stimulant thermogenic product. The result is a product covering major pathways of lipolysis in multiple, non-redundant, and synergistic ways, all without any neurological stimulation whatsoever.
Whether you’re taking a break from stimulants, are stimulant sensitive, or simply want a non-stimulant thermogenic to stack with our excellent stimulant-based offerings, Core SHRED is the perfect solution. Use it anytime, night or day, to help crush your regular exercise program and consistent diet!
L-carnitine is a derivative of the amino acid lysine and, as certain conditions outpace the body’s ability to produce it, l-carnitine is considered a conditionally essential amino acid. While endogenous biosynthesis of l-carnitine from the amino acids lysine and methionine is sufficient for essential processes – along with dietary sources of carnitine from protein-rich red meat, for example – dietary supplementation of carnitine may pose benefits in certain physiological conditions. Unfortunately, due to excess metabolism of l-carnitine by microorganisms in the small intestine, exogenous supplementation with oral l-carnitine has proved ineffective. ALCAR, an acetylated version of l-carnitine, has considerably higher oral bioavailability, due likely to only partial hydrolytic metabolism. Once in the bloodstream, ALCAR plays a fundamental role in the production of energy, acting as the catalyst for the beta-oxidation of long chain fatty acids by the mitochondria; regulating the CoA to Acyl-CoA ratio (necessary for the production of ATP); and the metabolism of carbohydrates. ALCAR also is an excitatory agent for neurons, increases neuronal transmission, and increases the production of neurotransmitters and neurohormones such as dopamine and serotonin.
Olea europaea, more commonly known as the olive, is a species of a small tree in the family Oleaceae, native to the coastal areas of southeastern Europe, western Asia and northern Africa, as well as northern Iran at the south end of the Caspian Sea. As the fruits, oils, and extracts ofOlea europaea L. are a dietary component for a significant portion of the world’s population, the plant has become associated with a wide-range of physiologic and metabolic benefits. These properties are largely attributed to the phenolic compounds of olive leaves, including: caffeic acid, verbascoside, oleuropein, luteolin 7-O-glucoside, rutin, apigenin 7-Oglucoside, and luteolin 4′-O-glucoside. Collectively, these olive polyphenols are responsible for a wide-range of postulated health benefits.
Oleuropein, in particular, is purported to have several pharmacological properties including antioxidant, anti-inflammatory, anti-atherogenic, and anti-microbial effects. Recent research inanimals has also demonstrated that oleuropein may potentiate the response of 5'-deiodinase, the enzyme responsible for the irreversible conversion of thyroxine (T4) into triiodothyronine (T3), the active thyroid hormone.
Coleus forskohlii root extract (20% forskolin):
Coleus forskohliiis a small perennial endemic to various tropical regions in the world, including South America, sub-Saharan Africa, and India. While the West has recently taken interest in the plant due to the pharmacological properties of its primary bioactive, forskolin, Coleus forskholii preparations and tinctures have been used in both South American and African traditional folk medicinal systems, as well as extensively within Ayurveda. Due to the ever-increasing interest in the plant’s verifiable pharmacological and physiological effects, however, Coleus forksholii and its extracted constituents have been the subject of numerous animal and human clinical trials in the past decade. These trials have demonstrated the plant to have various effects and applications, including as a lipolytic and anti-lipogenic, and as a powerful antioxidant.
A recent double-blind, randomized, and placebo-controlled human clinical trial featuring obese men found that the daily implementation of Coleus forskholii, for twelve weeks, led to significantly better weight loss outcomes as compared to controls. Overweight men in the forskolin group experienced not only improved body composition (as measured by both body fat percentage and total fat mass), but also statistically significant increases in lean body mass. Coleus forskholii – and more specifically, forskolin – achieves this effect by rapidly, potently, and dose-dependently increasing an important metabolic enzyme known as adenylate cyclase. Adenylate cyclase is an enzyme responsible for catalyzing the formation of cyclic adenosine monophosphate (cAMP) from adenosine triphosphate (ATP). This increase in cAMP formation eventually leads to the activation of an enzyme, protein kinase A, which in turn will phosphorylate and hence activate the enzyme, Hormone Sensitive Lipase (HSL) – the rate-limiting enzyme necessary for stored triglycerides within adipocytes to be released as free fatty acids and utilized for energy. In more basic terms, this means that forskolin quite literally frees up more fatty acids to be used as fuel for exercise – more or less the perfect scenario in a product such as Core SHRED!
CapsiAtra® is a dihydrocapsiate compound naturally found in CH-19 Sweet peppers. Like several other capsinoids identified and extracted from pepper species, CapsiAtra® has demonstrated potent effects on several physiological pathways – most notably, those related to energy expenditure and lipid utilization.
The thermogenic and lipolytic effects of capsinoids, like capsaicin itself, are mediated by the Transient Receptor Potential Vanilloid 1 (TRPV1) receptors in the mouth and throughout the gastrointestinal tract. TRPV1 receptors in the gut are linked with the sympathetic nervous system (SNS). When activated, they increase SNS activity (the figure below). TRPV1 receptors present on the tongue and in the oral cavity are responsible for, among other things, detection of thermal heat. When capsaicin binds to oral TRPV1 sites, one feels the sensation of heat and pungency. Capsinoids also stimulate TRPV1 receptors, but their effect is primarily on receptors in the throat and gut, not the mouth. Owing to the structural differences from capsaicin, the capsinoids are unable to reach the TRPV1 receptors on the tongue, which are located slightly below the mucosal surface. As a result, capsinoids do not produce the oral sensation of heat or the pungent taste associated with chili peppers, but they do produce the capsaicin-like SNS response once they bind to TRPV1 receptors in the throat and gut.
The capsinoids have multiple biological functionalities. The sports nutrition properties are directly linked to their use in energy manipulation. The capsinoids have three principal mechanisms of action. First, they up-regulate UCP-3 (Mitcohondrial Uncoupling Protein-3) in muscle cells. This causes ATP production to be dissociated with the respiration occurring in the mitochondria. This energy is then released as heat: an effect that is mirrored in caloric restriction as a means to economize energy. Second, they up-regulate UCP-1 (Uncoupling Protein-1, aka Thermogenin). This protein is only expressed in brown adipose tissue and is used to generate non- shivering thermogenesis; a process that evolved to protect against hypothermia. The up-regulation of UCP-1 can positively affect fat utilization and improve insulin sensitivity of tissues. Third, the capsinoids stimulate lipolysis via hydrolysis of triglycerides into glycerol plus three fatty acids. The release of these free fatty acids into the circulation is key to the energy regulating properties of the compound. Allowing these to become readily available as energy sources during exercise means that oxidation of muscle glycogen can be delayed, resulting in significant improvements in endurance.
Grains of Paradise Extract (12.5% 6-paradol)
Aframomum melegueta, more commonly known as Grains of Paradise, or the alligator pepper, is a plant in the Ginger (Zingiberaceae) family. While complete compositional analysis have not been performed on Grains of Paradise, preliminary assays demonstrate is structural and chemical similarity to ginger – principally in that both ginger and grains of paradise contains a range of pungent bioactives, one of which is 6-paradol.
Along with 6-shogaol, 6-paradol appears to be the most bioactive of the approximately 14 pungent compounds identified in ginger. Both compounds appear to potently and dose-dependently mediate the PI3K (phosphoinositide 3-kinase)/PKB (protein kinase B), leading specifically to an increase in AMPk phosphorylation. Known as the ‘master regulatory switch,’ AMPk is responsible for balancing endergonic (energy absorbing) and exogenic (energy liberating) processes in the body’s response to energy demands. AMPk is therefore heavily involved in adipocyte (fat cell) differentiation, proliferation, and hypertrophy, via regulating both enzymatic action (11B-HSD1, HSL, SREBP-1) and downstream lipogenic genes such as PPARy2.
In the case of gingerols such as 6-paradol, increased phosphorylation of AMPk in adipocytes appears to have a mitigating effect on hypertrophy by reducing lipid synthesis. 6-paradol appears to increase AMPk, which in turn decreases the mRNA expression of the downstream PPARy2 (peroxisome proliferate activated receptor gamma 2), a nuclear receptor gene principally responsible for lipid accumulation. In other words, the gingerols control a compound (AMPk) which, in turn, controls fat mass metabolism.