Core Nutritionals : Burn Ultra
Core Nutritionals’ Core BURN Ultra powder is that better way. There are no gimmicks here, no tricks and trade secrets. Just the very best, most verified-effective ingredients at serving sizes known to exert powerful effects on the human body. With Core BURN Ultra, we have taken many of the same ultra-potent ingredients found in Core BURN, mixed in a few amazing new friends, and put the whole thing in a delicious, convenient, and rapidly-dissolving powder. In the end, it’s your choice: flashy magazine ads, or an unrivaled and extreme thermo that plain, flat-out works as promised. If we had to choose between a slim wallet or a slim waist, we’d choose the latter – because we’d choose Core BURN Ultra.
Highlighted Ingredients of Core Burn Ultra:
- Garcinia Cambogia Fruit Extract
- Green Coffee Extract
- Coleus Forskohlii Root Extract
- Advantra-Z Orange Extract
To assess tolerance, mix 1 scoop with 8-12 oz of water and consume first thing in the morning. Am additional 1 scoop can be taken 5-6 hours later. Once tolerance is assessed, serving can be increased to 1 scoop before breakfast, 1 scoop after breakfast, and 1 scoop 5-6 hours later. Do not exceed 3 scoops in a 24 hour period. Do not use longer than 8 continuous weeks without a 4 week break.
Natural and Artificial Flavors, Citric Acid, Sucralose, Silicon Dioxide, Sodium Citrate, Potassium Chloride.
Core Nutritionals : Burn
Drop the kitchen sink approach and get surgical.
Core BURN is formulated with a diverse range of proven ingredients to create a powerful, balanced, and effective product. Core BURN is designed to target precise primary and secondary metabolic pathways, at multiple targets, to ensure maximum weight management.
- 2-3 capsules per serving.
- 75-50 servings per container.
- Jitter-free weight management.
Every week, there is a new story about a “breakthrough” or “miracle” substance that will make every other ingredient before it obsolete. Some of these claims may have merit, but the truth is that the biochemical processes of lipolysis are very complex and tightly regulated by the endocrine system and other biochemical pathways. Navigating this maze to effectively manage weight and body composition therefore requires more than a single, “miracle” compound: it involves numerous agents that together activate certain metabolic functions, while suppressing others. No single, “magic” compound does the job alone.
Core BURN is formulated to drop the kitchen sink and “miracle” ingredient tactics, and instead uses a diverse range of proven ingredients to create a powerful, balanced, and effective product. Core BURN is designed to target precise primary and secondary metabolic pathways, at multiple targets, to ensure maximum effectiveness. No more playing darts in the dark when it comes to weight management categories; randomly including ingredients, in whatever servings, hoping that something works. Specific. Multi-targeted. These words exemplify the new approach: amazing ingredients, in clinically-reflected serving sizes, all included in a non-proprietary blend so you know exactly what you’re consuming.
L-carnitine is a derivative of the amino acid lysine and, as certain conditions outpace the body’s ability to produce it, l-carnitine is considered a conditionally essential amino acid. While endogenous biosynthesis of l-carnitine from the amino acids lysine and methionine is sufficient for essential processes – along with dietary sources of carnitine from protein-rich red meat, for example – dietary supplementation of carnitine may pose benefits in certain physiological conditions.
Unfortunately, due to excess metabolism of l-carnitine by microorganisms in the small intestine, exogenous supplementation with oral l-carnitine has proved ineffective. ALCAR, an acetylated version of l-carnitine, has considerably higher oral bioavailability, due likely to only partial hydrolytic metabolism. Once in the bloodstream, ALCAR plays a fundamental role in the production of energy, acting as the catalyst for the beta-oxidation of long chain fatty acids by the mitochondria; regulating the CoA to Acyl-CoA ratio (necessary for the production of ATP); and the metabolism of carbohydrates. ALCAR also is an excitatory agent for neurons, increases neuronal transmission, and increases the production of neurotransmitters and neurohormones such as dopamine and serotonin.
Green Tea Extract (Camilla sinensis) (leaf) (50% EGCG):
Along with caffeine from the coffee plant, EGCG (Epigallocatechin gallate) from various sub-species of Camilla sinesis (green tea) is perhaps the most widely known and reputable anti-lipogenic and lipolytic agent in the world. Both compounds have well established anti-obesity effects, detailed in a deep body of literature featuring in vitro cell culture, as well as in vivo animal and human trials.
In animal and human studies, green tea generally and EGCG more specifically has been demonstrated to reduce the absorption of dietary lipids and modulate their subsequent metabolism, increase glucose utilization in resting states, as well as initiate de novo lipogenesis in both maximal and submaximal exercise states.
A two month dietary intervention, for example, showed that the daily consumption of a catechin-rich tea – EGCG is the most well-known of the catechins – by healthy humans led to a reduction of bodyweight of up to 20%, the consequence of increased lipolysis (as measured by FFA urinary clearance). A separate double-blind, placebo controlled trial using EGCG consumption both with, and without caffeine, demonstrated the increased oxidation of fatty acids within two hours of a meal – at level increases of 49% and 35%, respectively.
These studies suggest that EGCG not only exerts an inhibitory effect on the accumulation of lipids, but that it perhaps actively leads to the hydrolyzation of triglycerides for use as energy in the form of FFAs. In particular, this effect seems to be potentiated in the presence of caffeine ingestion, suggesting a synergistic effect between EGCG and caffeine on the hydrolyzation and subsequent oxidation of triglyceride stores.
Green Coffee Extract (Coffee arabica) (bean) (50% chlorogenic acid):
Chlorogenic acids (CGAs) are phenolic compounds created during the metabolism of various isoquinic acids found in the leaves of both coffee and tea. In addition to the well-established sympathomimetic effects of coffee and tea’s constituents, recent research has demonstrated a range of other potential benefits for compounds such as chlorogenic acids.
Recent literature suggests that the consumption of both green coffee, as well as standardized extracts of CGAs, relax the vasculature and improve vasoreactivity, impose an inhibitory effect on lipid accumulation and body weight in both mice and humans, and modulate glucose metabolism via the glucose-6-phosphate pathway.
Trials in both humans and mice using 1% extracts of green coffee bean revealed significant bodyweight reductions over periods of two and eight weeks. Researchers hypothesized that the bodyweight reductions associated with oral CGA administration was associated with the products numerous mechanisms of action, rather than a single, isolated cause.
Olive Extract (Olea europaeai) (leaf) (20% oleuropein):
Olea europaea, more commonly known as the olive, is a species of a small tree in the family Oleaceae, native to the coastal areas of southeastern Europe, western Asia and northern Africa, as well as northern Iran at the south end of the Caspian Sea.
As the fruits, oils, and extracts of Olea europaea L. are a dietary component for a significant portion of the world’s population, the plant has become associated with a wide-range of physiologic and metabolic benefits. These properties are largely attributed to the phenolic compounds of olive leaves, including: caffeic acid, verbascoside, oleuropein, luteolin 7-O-glucoside, rutin, apigenin 7-Oglucoside, and luteolin 4′-O-glucoside. Collectively, these olive polyphenols are responsible for a wide-range of postulated health benefits.
Oleuropein, in particular, is purported to have several pharmacological properties including antioxidant, anti-inflammatory, anti-atherogenic, and anti-microbial effects. Recent research in animals has also demonstrated that oleuropein may potentiate the response of 5'-deiodinase, the enzyme responsible for the irreversible conversion of thyroxine (T4) into triiodothyronine (T3), the active thyroid hormone.
Caffeine (1,3,7-trimethylxanthine) and Theomobrine (3,7-dimethyl-1H-purine-2,6-dione):
Caffeine is the most widely consumed, and perhaps one of the most reviewed, psychoactive compounds. Its physiological effects in a range of areas have been well-documented, including exercise performance, information processing, alertness and mood enhancement, attention, and awareness, along with its anti-lipogenic and lipolytic abilities. Caffeine is also the most well-known in the methylxanthine compound class, the constituents of which inter-metabolize into one another in the human body and largely share similar effects.
Various clinical trials have demonstrated that xanthines – including caffeine and theobromine – exert potent lipolytic (the breakdown of triglycerides into fatty acids) and oxidative actions as sympathomimetic amines. In less scientifically-complex parlance, this means caffeine is forcing your body to preferentially use adipose tissue as a fuel source for the oxidative provision of ATP (your body’s energy currency).
Evidence for xanthine’s capacity as lipolytic agents is widely available. In a clinical study featuring four separate trials in both normal and obese subjects, for example, caffeine was found to significantly increase fatty acid metabolism (as measured by serum fatty acid concentration), resting metabolic rate, and total fat oxidation – suggesting the preferential substrate selection spoken about above occurs in both normal and obese individuals. Other trials have demonstrated the effects of methylxanthines on total fat mass (reduction), lean body mass (increases), stamina and endurance, as well as cardiovascular capacity.
Additionally, as selective cAMP potentiators, through the beta-adrenergic pathway, caffeine and theobromine have been hypothesized to exert a synergistic effect on lipolysis when combined with forskolin.
Bacopa monnieri Extract (whole plant) (50% bacosides):
Bacopa monnieri (BM), also known as the water hyssop commonly, or as Brahmi in Ayurvedic texts, is a small creeping herb endemic to sub-tropical India. The herb has been used in traditional Indian medicine for well over one thousand years, with its first recorded usage coming in the 6th century A.D. In this traditional context, BM has been used for a wide-range of purposes, including as a treatment of asthma and epilepsy.
More recently, BM has been the subject of numerous cognition and memory trials, as the plant has a well-established nootropic effect. Likely through modulation of the serotonin reuptake system, clinical trials in healthy human beings have demonstrated that BM possesses a significant effect on the retention of newly-learned information. In several trials utilizing a 300mg daily serving, BM was also shown to decrease the recall delay of newly learned information and reduce short term forgetfulness – suggesting that the herb’s effect on the serotonic and cholinergic systems are increasing the encoding (the literal storing) of memory information.
Beyond cognition and memory encoding, BM has also been demonstrated to function as a potent adaptogen and relaxant – which in the Core BURN formula may help to smooth the effect curve of the product’s stimulants, reducing jitteriness or “crash.”
ForsLean® (Coleus forskohlii) (root) (20% forskolin): Coleus forskohlii is a small perennial endemic to various tropical regions in the world, including South America, sub-Saharan Africa, and India. While the West has recently taken interest in the plant due to the pharmacological properties of its primary bioactive, forskolin, Coleus forskholii preparations and tinctures have been used in both South American and African traditional folk medicinal systems, as well as extensively within Ayurveda.
Due to the ever-increasing interest in the plant’s verifiable pharmacological and physiological effects, however, Coleus forksholii and its extracted constituents have been the subject of numerous animal and human clinical trials in the past decade, primarily in its patented form of ForsLean. These trials have demonstrated the plant to have various effects and applications, including as a lipolytic and anti-lipogenic, and as a powerful antioxidant.
A recent double-blind, randomized, and placebo-controlled human clinical trial featuring obese men found that the daily implementation of ForsLean, for twelve weeks, led to significantly better weight loss outcomes as compared to controls. Overweight men in the ForsLean group experienced not only improved body composition (as measured by total non-lean mass), but also statistically significant increases in lean body mass.
In a separate 8 week trial, in overweight females, ForsLean was found to significantly reduce total bodyweight and significantly increase lean body mass relative to controls. Weight loss was statistically significant after 4 and 8 weeks and the mean amounted to 4.3 and 9.17 lbs respectively.
ForsLean – and more specifically, forskolin – achieves this effect by rapidly, potently, and dose-dependently increasing an important metabolic enzyme known as adenylate cyclase. Adenylate cyclase is an enzyme responsible for catalyzing the formation of cyclic adenosine monophosphate (cAMP) from adenosine triphosphate (ATP). This increase in cAMP formation eventually leads to the activation of an enzyme, protein kinase A, which in turn will phosphorylate and hence activate the enzyme, Hormone Sensitive Lipase (HSL) – the rate-limiting enzyme necessary for stored triglycerides within adipocytes to be released as free fatty acids and utilized for energy.
In more basic terms, this means that forskolin quite literally frees up more fatty acids to be used as fuel for exercise – more or less the perfect scenario in a product such as Core BURN!
Yohimbe Extract (Pausinystalia yohimbe) (bark) (8% Yohimbine alkaloids):
Extracts or preparation of Pausinystalia yohimbe, and related sub-species, have been used in traditional and folk medicinal systems such as Ayurveda and Unani for centuries. More recently, the principal bioactive compound in Pausinystalia yohimbe, both as a whole plant, and its extracted components, has been the subject of numerous clinical trials investigating its various physiological pathways.
In particular, recent research has shown that yohimbe bark extracts exert a powerful pre-synaptic inhibiting effect on alpha-adrenergic receptors – making it a potent adrenergic antagonist. This effect seems to be localized and largely specific to adipocytes, attaching to their adrenergic receptor sites and preventing them from receiving the catecholamines (norepinephrine and epinephrine) that would normally initiate growth signals.
While limited, there is some evidence in human, clinical trials to suggest that Yohimbine’s postulated mechanisms of action translate into practical effects. In a placebo-controlled trial involving 20 healthy, lean soccer players, subjects were given 20mg/day in two equal servings, for 21 days. At 21 days, the Yohimbine group reflected small but significant reductions in both total fat mass and bodyfat percentage as compared to controls – at least partially suggesting that Yohimbine may have a plausible role in combination with diet and exercise in weight management.
Advantra-Z® Bitter Orange Extract (Citrus aurantium) (fruit) (50% synephrine):
Synephrine is a naturally-occurring alkaloid with adrenergic agonist activity, structurally related to epinephrine, norepinephrine, ephedrine, and other compounds with a phenethylamine base structure. Despite its chemical similarity to these compounds, synephrine in its various isomers exerts unique effects on adrenergic receptors, in particular, and the human body, in general.
Synephrine exists in three isomer forms: para-, meta- and ortho-synephrine. The molecular changes between the three isoforms are minute, but even this small change results in significant alterations to each isomer’s physiological and pharmacokinetic profile. Two of synephrine’s isomers, both p- and m-synephrine, have been shown to naturally occur in mammals (in low concentrations). As a sympathomimetic, synephrine has been the subject of numerous trials, assessing its effects on weight management, thermogenesis, metabolic rate, and caloric expenditure. In a double-blind, randomized, and placebo-controlled trial involving 10 healthy individuals, the p-synephrine isomer was administered at a 50mg serving, both alone, and in combination with hesperidin and naringin. The authors measured resting metabolic rate (RMR), blood pressure, and heart rate, along with subjective feelings of mood and energy, at baseline, and at 45-mintues and 75-minutes after ingestion. The authors reported a significant increase in RMR in each of the supplement groups, relative to placebo.
In addition to studies on synephrine in its various isomers, Advantra-Z®, the specific form of synephrine utilized in Core BURN, has itself and in combination with other ingredients, been the subject of various clinical trials in humans. In a randomized, double-blind, placebo-controlled trial featuring 70 obese adults, a formulation containing Advantra-Z® was found to significantly reduce fat mass, body weight, and hip and waist girth as compared to controls, while leading to an increase in lean mass. As the authors comment, these results are in-line with a recent systematic review of human clinical studies involving Citrus aurantium, that revealed the ingredient to reliably increase resting metabolic rate up to 7.2%, increase energy expenditure of up to 13.4%, and weight loss of over 2.9 kg, with no serious adverse events in any of the trials.
In addition, the combination of caffeine and synephrine appears to potentiate each ingredient’s effects – with rates of fatty acid liberation, heart rate, metabolic rate, and fatty acid oxidation increased in clinical trials featuring the combination. In the same systematic review mentioned above, the authors note that the combination of synephrine and caffeine led to a small but significant reduction in fat mass of 3lbs, and a reduction in bodyfat of 2.9%.
Combined with not only caffeine, but the other ingredients in Core BURN, Advantra-Z® appears to be a potent weapon in the arsenal for body composition and weight management.
For references, see below file;
Core Nutritionals : SHRED Pineapple Strawberry
It’s late evening and you need to crush your workout – worst of all, your deep in a diet. You haven’t taken your thermogenic yet, you know you need to, but you also know that downing a few hundred milligrams of stimulants at 8 PM is not conducive to healthy sleep patterns. So, what do you do?
- 1 scoop per serving.
- 56 servings per container.
- Healthy thyroid support.
It’s late evening and you need to crush your workout – worst of all, your deep in a diet. You haven’t taken your thermogenic yet, you know you need to, but you also know that downing a few hundred milligrams of stimulants at 8 PM is not conducive to healthy sleep patterns. So, what do you do?
Prior to now, you sucked it up and chugged your ultra-potent and effective stimulant-based thermogenic (such as BURN or BURN Ultra!) and dealt with the consequences. But as of now, you take a scoop of the ultra-potent and equally effective, non-stimulant-based thermogenic Core SHRED.
We’ve taken our typical approach to product formulation – proven ingredients at clinically-effective and clinically-proven serving sizes – and applied it to creating a comprehensive, multiple-pathway non-stimulant thermogenic product. The result is a product covering major pathways of lipolysis in multiple, non-redundant, and synergistic ways, all without any neurological stimulation whatsoever.
Whether you’re taking a break from stimulants, are stimulant sensitive, or simply want a non-stimulant thermogenic to stack with our excellent stimulant-based offerings, Core SHRED is the perfect solution. Use it anytime, night or day, to help crush your regular exercise program and consistent diet!
L-carnitine is a derivative of the amino acid lysine and, as certain conditions outpace the body’s ability to produce it, l-carnitine is considered a conditionally essential amino acid. While endogenous biosynthesis of l-carnitine from the amino acids lysine and methionine is sufficient for essential processes – along with dietary sources of carnitine from protein-rich red meat, for example – dietary supplementation of carnitine may pose benefits in certain physiological conditions. Unfortunately, due to excess metabolism of l-carnitine by microorganisms in the small intestine, exogenous supplementation with oral l-carnitine has proved ineffective. ALCAR, an acetylated version of l-carnitine, has considerably higher oral bioavailability, due likely to only partial hydrolytic metabolism. Once in the bloodstream, ALCAR plays a fundamental role in the production of energy, acting as the catalyst for the beta-oxidation of long chain fatty acids by the mitochondria; regulating the CoA to Acyl-CoA ratio (necessary for the production of ATP); and the metabolism of carbohydrates. ALCAR also is an excitatory agent for neurons, increases neuronal transmission, and increases the production of neurotransmitters and neurohormones such as dopamine and serotonin.
Olive Extract (Oleaeuropaeai) (leaf) (20% oleuropein):
Olea europaea, more commonly known as the olive, is a species of a small tree in the family Oleaceae, native to the coastal areas of southeastern Europe, western Asia and northern Africa, as well as northern Iran at the south end of the Caspian Sea. As the fruits, oils, and extracts of Olea europaea L. are a dietary component for a significant portion of the world’s population, the plant has become associated with a wide-range of physiologic and metabolic benefits. These properties are largely attributed to the phenolic compounds of olive leaves, including: caffeic acid, verbascoside, oleuropein, luteolin 7-O-glucoside, rutin, apigenin 7-Oglucoside, and luteolin 4′-O-glucoside. Collectively, these olive polyphenols are responsible for a wide-range of postulated health benefits.
Oleuropein, in particular, is purported to have several pharmacological properties including antioxidant, anti-inflammatory, anti-atherogenic, and anti-microbial effects. Recent research inanimals has also demonstrated that oleuropein may potentiate the response of 5'-deiodinase, the enzyme responsible for the irreversible conversion of thyroxine (T4) into triiodothyronine (T3), the active thyroid hormone.
Coleus forskohlii root extract (20% forskolin):
Coleus forskohlii is a small perennial endemic to various tropical regions in the world, including South America, sub-Saharan Africa, and India. While the West has recently taken interest in the plant due to the pharmacological properties of its primary bioactive, forskolin, Coleus forskholii preparations and tinctures have been used in both South American and African traditional folk medicinal systems, as well as extensively within Ayurveda. Due to the ever-increasing interest in the plant’s verifiable pharmacological and physiological effects, however, Coleus forksholii and its extracted constituents have been the subject of numerous animal and human clinical trials in the past decade. These trials have demonstrated the plant to have various effects and applications, including as a lipolytic and anti-lipogenic, and as a powerful antioxidant.
A recent double-blind, randomized, and placebo-controlled human clinical trial featuring obese men found that the daily implementation of Coleus forskholii, for twelve weeks, led to significantly better weight loss outcomes as compared to controls. Overweight men in the forskolin group experienced not only improved body composition (as measured by both body fat percentage and total fat mass), but also statistically significant increases in lean body mass. Coleus forskholii – and more specifically, forskolin – achieves this effect by rapidly, potently, and dose-dependently increasing an important metabolic enzyme known as adenylate cyclase. Adenylate cyclase is an enzyme responsible for catalyzing the formation of cyclic adenosine monophosphate (cAMP) from adenosine triphosphate (ATP). This increase in cAMP formation eventually leads to the activation of an enzyme, protein kinase A, which in turn will phosphorylate and hence activate the enzyme, Hormone Sensitive Lipase (HSL) – the rate-limiting enzyme necessary for stored triglycerides within adipocytes to be released as free fatty acids and utilized for energy. In more basic terms, this means that forskolin quite literally frees up more fatty acids to be used as fuel for exercise – more or less the perfect scenario in a product such as Core SHRED!
CapsiAtra® is a dihydrocapsiate compound naturally found in CH-19 Sweet peppers. Like several other capsinoids identified and extracted from pepper species, CapsiAtra® has demonstrated potent effects on several physiological pathways – most notably, those related to energy expenditure and lipid utilization.
The thermogenic and lipolytic effects of capsinoids, like capsaicin itself, are mediated by the Transient Receptor Potential Vanilloid 1 (TRPV1) receptors in the mouth and throughout the gastrointestinal tract. TRPV1 receptors in the gut are linked with the sympathetic nervous system (SNS). When activated, they increase SNS activity (the figure below). TRPV1 receptors present on the tongue and in the oral cavity are responsible for, among other things, detection of thermal heat. When capsaicin binds to oral TRPV1 sites, one feels the sensation of heat and pungency. Capsinoids also stimulate TRPV1 receptors, but their effect is primarily on receptors in the throat and gut, not the mouth. Owing to the structural differences from capsaicin, the capsinoids are unable to reach the TRPV1 receptors on the tongue, which are located slightly below the mucosal surface. As a result, capsinoids do not produce the oral sensation of heat or the pungent taste associated with chili peppers, but they do produce the capsaicin-like SNS response once they bind to TRPV1 receptors in the throat and gut.
The capsinoids have multiple biological functionalities. The sports nutrition properties are directly linked to their use in energy manipulation. The capsinoids have three principal mechanisms of action. First, they up-regulate UCP-3 (Mitcohondrial Uncoupling Protein-3) in muscle cells. This causes ATP production to be dissociated with the respiration occurring in the mitochondria. This energy is then released as heat: an effect that is mirrored in caloric restriction as a means to economize energy. Second, they up-regulate UCP-1 (Uncoupling Protein-1, aka Thermogenin). This protein is only expressed in brown adipose tissue and is used to generate non- shivering thermogenesis; a process that evolved to protect against hypothermia. The up-regulation of UCP-1 can positively affect fat utilization and improve insulin sensitivity of tissues. Third, the capsinoids stimulate lipolysis via hydrolysis of triglycerides into glycerol plus three fatty acids. The release of these free fatty acids into the circulation is key to the energy regulating properties of the compound. Allowing these to become readily available as energy sources during exercise means that oxidation of muscle glycogen can be delayed, resulting in significant improvements in endurance.
Grains of Paradise Extract (12.5% 6-paradol)
Aframomum melegueta, more commonly known as Grains of Paradise, or the alligator pepper, is a plant in the Ginger (Zingiberaceae) family. While complete compositional analysis have not been performed on Grains of Paradise, preliminary assays demonstrate is structural and chemical similarity to ginger – principally in that both ginger and grains of paradise contains a range of pungent bioactives, one of which is 6-paradol.
Along with 6-shogaol, 6-paradol appears to be the most bioactive of the approximately 14 pungent compounds identified in ginger. Both compounds appear to potently and dose-dependently mediate the PI3K (phosphoinositide 3-kinase)/PKB (protein kinase B), leading specifically to an increase in AMPk phosphorylation. Known as the ‘master regulatory switch,’ AMPk is responsible for balancing endergonic (energy absorbing) and exogenic (energy liberating) processes in the body’s response to energy demands. AMPk is therefore heavily involved in adipocyte (fat cell) differentiation, proliferation, and hypertrophy, via regulating both enzymatic action (11B-HSD1, HSL, SREBP-1) and downstream lipogenic genes such as PPARy2.
In the case of gingerols such as 6-paradol, increased phosphorylation of AMPk in adipocytes appears to have a mitigating effect on hypertrophy by reducing lipid synthesis. 6-paradol appears to increase AMPk, which in turn decreases the mRNA expression of the downstream PPARy2 (peroxisome proliferate activated receptor gamma 2), a nuclear receptor gene principally responsible for lipid accumulation. In other words, the gingerols control a compound (AMPk) which, in turn, controls fat mass metabolism.
For references, see below file;
Core Nutritionals : Load
We suggest that every other GDA bend the knee.
Core LOAD has changed the meaning of “glucose-disposal agent” (GDA). While most GDAs on the market are single-pathway or single-mechanism formulas with sub-clinical serving sizes, LOAD targets multiple pathways and mechanisms through supra-clinical serving sizes.
- Serving size 6 capsules.
- 30 servings per container.
- Carb-proof your diet.
With the advent of Core LOAD, Core Nutritionals has effectively changed the meaning of glucose-disposal agent (GDA). While most GDAs on the market are single-pathway or single-mechanism formulas with sub-clinical serving sizes, Core LOAD targets multiple pathways and mechanisms through either clinical or supra-clinical serving sizes. And most importantly, Core LOAD reaches these pathways through several non-redundant key ingredients that surgically target both glycogenic (glycogen-creating) and lipolytic (lipid/fat tissue-mitigating) pathways.
Core LOAD’s success as a GDA is due to its key ingredients – and specifically, the major pathways of glycogen storage and lipid metabolism they alter. Specifically, increasing the translocation of GLUT4 from the cell nucleus (its inner portion) to the periphery (its outer portion), thereby increasing the transportation of glucose into the cell; by inhibiting PPAR-Gamma2 and other critical lipogenic/lipolytic genes and gene pathways; by altering the response to glucose ingestion at the cellular level; and by altering other critical messengers in both the glycogenic and lipolytic pathways.
While other GDAs may target similar pathways, Core LOAD contains several ingredients that target these pathways through several different, non-redundant mechanisms. Essentially, we have taken every possible step to maximize your body’s glycogen storage, rather than relying on a single ingredient approach. Perhaps more importantly, we have utilized ingredients such a CGA (chlorogenic acid – a component of green coffee extract) in ways and serving sizes that blow the competition away. While serving sizes as small as 300mg of GGA have been shown to assist in healthy weight management, we included a savage 2g serving! That serving is also anywhere from 3-10x the serving size found in clinical research assessing CGA’s impact on glucose homeostasis and glycogen formation.
Now, the critical question, not just for CGA, but for all glucose disposal agents is this: why is “disposing” of glucose important? What does that even mean. Let’s break this down in two ways. Let’s consider the first way as (attempting) to increase lean tissue; and the other avoiding non-lean tissue. When you consume carbohydrates, your body breaks those carbohydrates down until they eventually reach the plasma (blood) as glucose – blood sugar. Blood sugar is then diverted to cells for consumption in bodily processes.
Our bodies divert glucose to both muscle cells (good) and fat cells (bad). In terms of the good, lean tissue-increasing effects, the key ingredients in Core LOAD will assist your body in creating glycogen. Think of glycogen like NOS for a car: a car can certainly run on fuel alone, but adding NOS to the mix greatly boosts the vehicle’s speed. For short bursts of maximal or near-maximal effort exercise, glycogen functions as your body’s fuel source – in addition to filling muscle bellies to provide them a “full,” 3D look. Maximizing glycogen storage also acts like an insurance policy against lipogenic (fat tissue-creating) action: the more glycogen stored in muscle, the less glucose shuttled to adipose cells or to the liver.
In terms of the bad, your body also diverts glucose to adipose (fat) cells – but not for energy consumption, but energy storage. Consider fat cell’s the long term storage bunker of your body: your body puts glucose there to withdraw it in times of need. Core LOAD’s key ingredients inhibit the process in non-redundant, synergistic ways – from inhibiting glucose uptake at the gastrointestinal level (to stabilize plasma glucose, which diminishes uptake in adipose cells) to diminishing the activity of key lipogenic (fat mass increasing) genes.
When you combine both of these two kinds of action, you get Core LOAD: the new king of GDAs. We suggest that every other product bend the knee.
Green Coffee Extract (Coffea robusta) (bean) (50% Chlorogenic acid)
Coffee is widely recognized as not only the most consumed psychoactive compound on earth, but perhaps also the most consumed plant material in general. Due to the extent of coffee consumption by humans, several species of coffee beans, along with their bioactive constituents, have been research targets for a number of therapeutic pathways. The most abundant polyphenol in coffee is Chlorogenic acid (CGA). An abundance of data suggests that CGA has numerous physiological properties, and that its most potent physiological effects are hypoglycemic (blood sugar-lowering) and lipolytic/anti-lipogenic in nature. Recent evidence demonstrates that CGA is a powerful and novel glucose modulator, in vivo, in both healthy and diseased populations.
Research shows that one of CGA’s potential hypoglycemic mechanisms is insulin sensitization – in other words, making existing cells more sensitive to the glucose shuttling effects of insulin. In a trial on streptozotocin (STZ) (45 mg/kgbw) nicotinamide-induced diabetic rats, a 5mg/kgbw dose of CGA significantly mitigated the diabetic effects of STZ and caused an increase to glucose uptake. Of note, the 5mg/kgbw dose of CGA used in the animal trial is significantly less than the mg/kgbw serving size of CGA included in Core LOAD. (Assuming an average Core LOAD consumer bodyweight of 75kg.) An additional trial in obese Zucker rats demonstrated that CGA is capable of improving glucose tolerance and insulin resistance. The trial found that the CGA group had better glucose tolerance, higher insulin sensitivity index (ISI), and lower HOMA-IR (insulin resistance) index.
A trial in healthy humans showed similar promise. Healthy, human subjects were challenged with an acute serving of CGA and then assessed for hepatic glucose output, blood glucose levels, and glucose tolerance. CGA induced a significant reduction in peak plasma glucose levels – an important fact, as glucose fluctuations and/or chronically excessive blood glucose levels are associated with fat cell proliferation. Unlike the animal trial, however, the human trial hypothesized that CGA worked through a different, more novel mechanism: attenuating glucose absorption in the gastric uptake phase. In this trial, CGA effectively CGA functioned as both an insulin sensitizing agent and a glycemic index lowering agent.
In addition to both the above mechanisms, CGA was shown to inhibit the activities of α-amylase and α-glucosidase – two enzymes responsible for metabolizing carbohydrates into saccharides. As a result, CGA again reduced postprandial (post-meal) blood glucose concentration. The potentially novel glycemic index-lowering and carbohydrate metabolism effects of CGA were confirmed in two further trials: one in which CGA intake significantly reduced fasting glucose and insulin levels in obese men, and another in which CGA lowered the glycemic impact (how quickly and to what degree plasma glucose was increased) and lowered blood glucose levels.
CGA is an interesting compound due not only to its potent insulin-sensitizing and glycemic effects, but also its novel action on lipid metabolism. A 2006 trial found that CGA – in addition to caffeine and other polyphenols found in green coffee bean extract – suppressed body weight gain and the accumulation of visceral fat in mice. Again, the mechanism of action was quite unique: CGA was found to inhibit and delay the absorption of fat at the gastric uptake phase and reduce lipid metabolism in the liver.
In a separate trial on obese rates, CGA significantly reduced body weight, visceral fat mass (adipose tissue surrounding the internal organs), and plasma insulin concentrations. The authors of this trial hypothesize that, in addition to the profound effects on glucose metabolism noted above, CGA reduced body weight and fat mass due to increased fatty acid beta-oxidation activity and peroxisome proliferator-activated receptors alpha expression in the liver.
In sum, CGA is the perfect confluence of glycogenic, glycemic-impact lowering, insulin sensitizing, and anti-lipogenic factors. Its inclusion as a key ingredient in Core LOAD, at well above clinical serving sizes, functions to promote healthy blood glucose levels, healthy bodyweight, and healthy insulin release.
GS4 Plus® Gymnema sylvestre Extract (leaves) (25% gymnemic acids)
Gymnema sylvestre is a plant endemic to the tropical and sub-tropical regions of Southeast Asa, including India and China. In these countries, G. sylvestre functions as a treatment for many pathological conditions, including diabetes and hypercholesterolemia – in fact, the Ayurvedic name for G. sylevestre is “Gurmar,” or “destroyer of sugars.” The principle bioactives in G. sylvestre, gymnemic acids, are concentrated highly in the leaves and have been isolated and observed for their glucose shuttling properties.
In a clinical trial in humans using a G. sylestre extract dietary supplement, 65 participants were administered G. sylvestre for 90 days. After the 90 day treatment, the participants were assessed for a number of biometrics, including prenadial (pre-eating) plasma glucose concentrations and HbA1c (haemoglobin A1c, a key marker for diabetes) levels. The researchers found that 90 days of supplementation with G. sylvestre lowered prenadial blood glucose by 11%, postpranadial glucose by 13%, and Hb1Ac by .8% (a seemingly small figure, but in fact statistically significant).
In another, small clinical study, fasting blood glucose levels significantly improved in a group of type II diabetes mellitus patients after receiving a 200mg extract of G. sylevestre (standardized for gymnemic acid) for 20 months.
Unlike CGA, the mechanism(s) of action for G. sylevestre and gymnemic acid have not been precisely identified. Several trials in rats suggest that gymnemic acid’s structural similarity to glucose may have a role in its hypoglycemic effects; while still other trials suggest that, like CGA, gymemic acid may exert glucose uptake inhibitory effects at the intestinal level.
Whatever the mechanism of action, however, the plant has demonstrated the ability to promote healthy blood glucose levels and assist in the management of a healthy body mass.
Berbis aristata Extract (bark) (97% berberine)
Berberis aristata, is a shrub belonging to the family Berberidaceae and the genus Berberis, found in many parts of Eurasia and the Americas. The bark and bark extracts of the plant have been used traditionally as an antibacterial and antifungal preparation and as a hypoglycaemic, anti-diuretic, and vasodilator. The use of both B. aristata and its principal constituent, berberine, is widespread in traditional medicinal systems throughout history. Berberine is also now a prominent ingredient in dietary supplement formulations and a research target for numerous pathological conditions.
There is extensive literature demonstrating that the bark extract of B. aristata – and other plants containing a large proportion of berberine – is a potent AMPk agonist in skeletal muscle. Based on the pharmacological similarities between berberine and the anti-diabetic medicine metformin (with respect to AMPk activation), it is possible that berberine may promote an anti-catabolic state through increased expression of AMPk. In a randomized, placebo-controlled and double blind trial, patients with Type II diabetes mellitus risk factors were administered an oral preparation of 650mg Metformin for 8 weeks to assess body composition and changes in insulin resistance. The Metformin group experienced an increase in lean weight from 57.05 +/- 13.6 to 61.9kg +/- 16.5 kg (p < 0.01). Though the standard deviation suggests a large variation in lean tissue gain, the results are taken to be statistically significant at the 99th confidence interval, suggesting a high level of statistical precision. This indicates, in other words, that 99% of the study population experienced a lean weight increase. It should be noted that, in comparison studies, berberine extracts (at doses of 500-1500 mg/day) have outperformed metformin in key biochemical and physiological markers: including AMPk phosphorylation.
The human data – in both healthy and disease state populations – demonstrating berberine’s other physiological effects are numerous. A 2012 meta-analysis examined 14 randomized trials, containing 1068 patients, and assessed berberine’s efficacy in numerous biometrics, including resting plasma glucose levels, plasma insulin levels, body weight, body mass index, and reduction in fat mass and serum triglycerides and total cholesterol content. The aggregate data suggests that berberine performs at least as well as oral hypoglycemic agents (such as metformin) in these key metrics. Perhaps most interesting for users of Core LOAD, berberine showed the most promise in combination with oral hypoglycemic agents. While berberine lowered fasting plasma glucose and insulin levels, reduced HbA1c, reduced triglyceride levels and reduced fat mass alone, and performed well in comparison, it was shown to potentiate the effects of pharmaceutical anti-diabetics – at times significantly, with further reductions in the above metrics of up to 20%.
Effectively, this means that berberine is not only a potent glucose disposal agent on its own, but also makes other glucose disposal agents more effective.
Like CGA, berberine is not only a glucose disposal agent but a potent anti-lipidemic agent. In in vitro models, researchers examined the expression of a number of adipocyte-specific genes including fatty acid synthase (FAS), ADD1/SREBP1c (adipocyte determination and differentiation–dependent factor 1/sterol regulatory element–binding protein 1c), peroxisome proliferator–activated receptor (PPAR)γ, and 11β-hydroxysteroid dehydrogenase 1 (11β-HSD1), and found them to be reduced in various WAT (white adipose tissue) deposits of berberine-treated mice. This data suggests that daily ingestions of beberine may potently inhibit a constellation of genes that are responsible for both depositing and converting lipids into fat tissue, and genes responsible for their mobilization (use for fuel) in response to exercise. In brown adipose tissue, the expression of PPARα mRNA (a receptor protein largely involved in lipolysis – the breakdown of fat tissue) also increased dramatically, while the mRNA of lipogenic genes such as FAS was reduced. Additionally, expression of PPARγ coactivator-1, a key regulator of several mitochondrial genes involved in adaptive thermogenesis, was substantially increased, suggesting berberine’s induction of AMPk expression leads to an inhibition of the proliferation and hypertrophy of fat cells.
Again, like CGA, berberine possesses numerous, beneficial physiological and metabolic properties: including the healthy regulation of blood glucose and accumulation of fat tissue. But perhaps most importantly, the evidence suggests that berberine may potentiate the effects of every other ingredient in Core LOAD.
Banaba Extract (Lagerstroemia speciose)(leaf)(20% corosolic acids)
Lagerstroemia speciosa is a flowering tree of the Lagerstroemia genus that is native to large portions of south east Asia, India and the Phillipines, and its bark and leaves have a historical tradition in folk medicine for the treatment of diabetes mellitus. Banaba (L. speciosa’s common name) has been used as a folk medicine to treat diabetes in various parts of the world, primarily southeast Asia. The hypoglycemic effect of aqueous (hot water) and methanol extracts have been demonstrated in many human studies. Most studies have focused on corosolic acid, the primary bioactive constituent of L. speciosa – and the compound for which Core LOAD’s banaba is standardized.
A 12-week lifestyle intervention study, involving 56 subjects consuming a dietary supplement containing banaba, taken prior to each meal, measured body mass at the conclusion of the trial. At the end of 12 weeks, the subjects had lost an average of 6.29 kg (13.8 lb) including 3.72 kg (8.2 lb) body fat as determined by a bioelectric impedance body fat analyser.
In a separate, smaller study, 12 nondiabetic subjects with a baseline blood glucose level of 104 mg/dL were given a soft gel capsule daily for 2 weeks containing 10 mg corosolic acid as a Banaba extract standardized to 18% corosolic acid. A 12% decrease in fasting glucose levels, as well as 60 min postprandial blood glucose levels, was observed after 2 weeks of administering the product. The authors also reported an average three-pound weight loss after the two weeks.
In an unpublished study using the same soft gel product containing 10 mg corosolic acid, 100 subjects with prediabetes or type 2 diabetes were enrolled. Half the subjects were given one soft gel containing the corosolic acid-standardized Banaba extract and the other half received a placebo for 30 days. Both fasting and 2 h postprandial blood glucose levels in the treated group decreased by 10% relative to the control (placebo) group. Also reported was an improvement in diabetic symptoms including a decrease in thirst, drowsiness, and hunger. Furthermore, no adverse effects were observed, with no changes in blood pressure, liver or kidney function, blood cell count, or hemoglobin.
Lastly, a study involving 31 subjects in a double-blind cross-over design were given a capsule containing 10 mg corosolic acid or a placebo 5 min before a 75g oral glucose tolerance test. Blood glucose levels were measured at 30 min intervals for 2h. The authors reported that corosolic acid treatment resulted in lower blood glucose levels from 60 to 120 min compared with controls, the difference being statistically significant (P < 0.05) at the 90 min time point. According to the authors, the corosolic acid that was used was 99% pure, thus indicating that the blood sugar lowering effect was specifically due to the corosolic acid. In the context of Core LOAD, the AUC (area under curve) demonstrated in this trial is important – as it demonstrates that corosolic acid exerts glucose stabilizing effects over a long time period (such as immediately before-to-after an intense workout).
The above clinical studies demonstrate that Banaba extract, Banaba extract standardized to corosolic acid, and corosolic acid itself, decrease fasting as well as postprandial blood glucose levels in humans. A decrease in blood glucose levels has been observed within 2 h of dosing, and the decrease is typically in the range of 10–15%, although a decrease of 30% has been reported.
The ability to corsolic acid to positively regulate healthy plasma glucose levels makes it a key addition to Core LOAD’s glucose disposal agent lineup.
For references, check below file;