Core Nutritionals: HARD Extreme Pineapple Strawberry
To be hard, you need to get HARD. It's that simple.
Core HARD is the pinnacle in recomposition supplementation. The ingredients in HARD have been specifically chosen to balance your hormonal environment and maximize your lean mass.
- 3 scoops per serving.
- 28 servings per container.
- Body recomposition.
Your diet is impeccable and couldn’t be any more in check – macros, micros, you have it all down. Your workouts? Get out of here! You have slaved, grinded, and grunted your way through leg workouts so intense the gym staff cried – and those were on your worst days. And yet, something is missing.
It’s that “extra” level of shred, “that look.” You know exactly what we mean. That type of leanness and density that makes an arm look twice as big, a stomach look twice as lean, and a forearm look like a roadmap for the Italian countryside. It’s that kind of elusive hardness that’s so rare, most of us simply chalk it up to genetics, or luck, or steroids, or whatever excuse we have handy – and yet we all still want it.
The reality? It isn’t all that unattainable. Getting “that” look, “that” hardness, is about balance and recomposition. It’s a matter of adding in that final piece of the puzzle that makes the entire picture come out perfectly.
To be hard, you need to get HARD. It’s that simple.
Core HARD is another product in the Core Nutritionals’ lineup to follow the basic, but indispensable principles that Core Nutritionals is slowly making an industry standard: create products with effective ingredients, in effective doses, in a non-proprietary formula. This time around, we have applied those principles to the problem of softness that we all despise and have developed the most advanced ultra-hardening and recomposition agent on the market.
Taking advantage of both the old and the new, Core Nutritionals has employed both modern, cutting-edge compounds and traditional herbs to create a balanced approach to delivering hardness. Key ingredients in Core HARD affect some of the body’s critical physiological pathways, combining sexiness and science in a single, non-proprietary formula. We have included seven powerful ingredients into a full month's worth of stimulant free, recomposition goodness.
KSM-66® Full-Spectrum Ashwagandha Extract (Withania somnifera) (root) (5% withanolides)
Withania somnifera Dunal, colloquially known as Winter Cherry or Indian Ginseng, is an herb that features prominently in the traditional Indian medicinal system of Ayurveda. Known as Ashwagandha in Ayurveda, Withania somnifera is a critical ingredient in various Ayurvedic tonics and tinctures prepared as a traditional remedy for the treatment of various ailments.
Recently identified as a potent adaptogenic and target for therapeutic applications, Ashwaghanda has been the subject of numerous animal, pre-clinical, and clinical trials designed to examine its potential effects as an antioxidant, anti-carcinogenic, anxiolytic, antibacterial, antifungal, and immonumodulating compound. Ashwaghanda’s broad therapeutic potential is hypothesized to be the result of its robust phytochemical profile, including a wide swath of alkaloids, sitoindosides, and the highly biologically active withanolide group. As the principally biologically active compounds within Ashwaghanda, withanolides such as withanone, withaferine A, withanolides A, D, and G have been identified, isolated, and extensively studied in the various applications noted above.
In recognition of the potential physiological benefits of withanolides, Core Nutritionals selected KSM-66® to include in its HARD formula. KSM-66® is a full-spectrum Ashwaghanda extract, standardized for 5% withanolides – meaning that KSM-66® not only includes the full range of biologically active compounds within Ashwaghanda, but also that it contains the highest currently available concentration of the principally active withanolides (5%).
The high concentrations of withanolides within KSM-66® has resulted in encouraging results in a number of human, clinical trials – particularly considering many of these trials were conducted using the methodological gold standard of randomization, double-blind delivery, and placebo control. Amongst the most impressive results contained in these trials:
- A 27.9% reduction in serum cortisol levels, measured over 60 days in a trial featuring 64 chronically stressed adults.
- Statistically significant increases to endurance and stamina, as measured by VO2 max, in a clinical trial featuring 50 healthy, exercise-trained adults.
- Increased measures of well-being as reported by self-assessment scales, included in both the clinical trials mentioned above.
- Statistically significant increases in serum testosterone levels in a clinical trial featuring 68 infertile men.
Though each of these results is impressive, perhaps the most significant is the 27.9% reduction in cortisol seen in the 60 day trial. As detailed above, cortisol possesses a multitude of potentially degradative physiological effects, including: inhibiting glucose uptake, causing a constriction of the vasculature (vasoconstriction), the breakdown of glycogen, and inarguably the result most would desire to avoid, proteolysis (the breakdown of muscle tissue).
Phosphatidylserine, colloquially known as PS, is a nearly ubiquitous phospholipid found in various membranous tissues throughout the body. PS’s ubiquity coincides with its necessity for crucial physiological functions, as the phospholipid is implicated in several components of cell communication, as well as the mediation of catecholamine synthesis and transmission in the brain (along with other neuroendocrine functions). In a fitness-related context, a nascent but growing body of methodologically-sound research suggests that PS may play a role in increasing exercise capacity.
Studies administering the compound in both acute and chronic fashion suggest that PS has a measurable effect on exercise capacity. In a double-blind, placebo-controlled, randomized trial involving 16 trained athletes, phosphatidylserine was administered for 10 days prior to an acute exercise challenge. Exercise markers such as exercise time to exhaustion, sprint performance, and ratings of perceived exertion, were measured post-exercise. The authors found that exercise time to exhaustion was significantly altered. Related studies using similar serving sizes have found that chronic PS administration increased shot accuracy in golfers, increased exercise time to exhaustion by 28% in cyclists, and reduced subjective feelings of stress and soreness in others.
Overall, phosphatidylserine appears to play a valuable role in the increase in exercise capacity. PS may therefore play a critical role in the continued exercise success of bodybuilders in a, “cutting” or recomposition stage.
Pomegranate Extract (Punica granatum) (hull) (ellagic acid 40%)
Pomegranate is a fruit-bearing deciduous shrub, endemic to and cultivated in wide swaths of both Europe and Asia. Pomegranate is also the predominant member of two species comprising the Punicaceae family
Pomegranate fruit has long been consumed as a dietary staple, and recent research has uncovered that the peel, in particular, harbors a broad range of physiologically active compounds known as polyphenols – most prominently ellagitannins. When consumed, these ellagitannins are hydrolyzed to ellagic acid in the gut, and released into the blood, allowing ellagic acid to be widely distributed to many target tissues and organs.
While still preliminary, emerging animal and in vitro data on PME (pomegranate extract) suggests that both specific and whole plant extracts may exert interesting endocrine effects. In a study examining the effects of PME on cultured human cells, PME was shown to down-regulate estrogen-receptor gene expression, and inhibit binding – suggesting that PME may possess some anti-estrogenic effects, at least in vitro. In another study in rats, PME’s robust antioxidant profile was hypothesized to increase androgenic activity via reducing oxygen radicals in the testes.
Though PME lacks robust human data, the available literature suggests that this compound may possess some highly useful physiological effects.
White Button Mushroom Extract (Agaricus blazei) (fruit) (30% polysaccharides)
Agaricus blazei, known commonly by a plethora of names – including button mushroom, white button mushroom, table mushroom, and champignon mushroom – is a small, edible mushroom endemic to North America and Europe. The most commonly consumed mushroom on the planet, commercial production and consumption of white button mushroom has existed since at least the early 18th century, while indigenous oral records suggest the plant was consumed for centuries prior.
Recent medical research has discovered that white button mushroom is a rich source of biologically-active compounds, including ergothioneine, an antioxidant with particularly potent free radical scavenging activity. Similar research has found that white button mushrooms – along with other varieties – possess unsaturated fatty acids such as linoleic acid, linolenic acid, and conjugated linoleic acid that may exert inhibitory activity on human aromatase, a cytochrome-P450 complex responsible for the conversion of testosterone into estrogen.
In two separate studies by similar researchers, both rats and human cell lines were fed and/or incubated with various extract strengths and doses of white button mushroom extract. Both the animal experiments and “in-cell” aromatase assays demonstrated that WBME exerted powerful anti-aromatase effects, reducing total aromatase amounts and activity across all experimental conditions.
The most encouraging aspect of these studies is the servings of white button mushroom used in the experimental conditions: they are easily achievable through oral consumption, unlike many other plant-based, physiologically active compounds.
Though the literature surrounding L-theanine is still emerging, the amino acid is slowly building a reputation as one of the most interesting and exciting compounds being targeted for therapeutic use. L-theanine is an amino acid found almost exclusively in tea, constituting approximately 1-2% of the dry weight of tea – resulting in a 25–60 mg theanine load per 200 ml serving of liquid tea.
First identified in green tea and in the mushroom Xerocomus badius, L-theanine readily crosses the blood-brain barrier in a dose-dependent manner, and it is thought to inﬂuence the central nervous system (CNS) through a variety of mechanisms, including:
- Inhibiting glutamate reuptake and blockade of glutamate receptors in the hippocampus.
- Increasing gamma-aminobutyric acid (GABA – a neurotransmitter associated with the regulation of responses) concentrations.
In addition to these more well-demonstrated effects, emerging electroencephalography trials on theanine suggest that the amino acid may exert a positive effect on alpha waves – a type of brain wave implicated in restful relaxation. Alpha activity has also been associated with increased creativity, increased performance under stress, and improved learning and concentration, as well as decreased anxiety.
What we typically refer to as “Estrogen,” is in fact a group of three biologically distinct hormones – estradiol (E2), estrone (E1), and estriol (E3), each possessing different activities in different cell, tissue, and receptor types. When experts refer to either the benefits or downfalls of “estrogen," they really mean to identify a specific estrogen.
These specific estrogens, in turn, metabolize into even more specific estrogen sub-compounds, such as the 2-hydroxyestrogens (2-OHE’s), 2-methoxyestrogens, 16a-hydroxyestrone (16-OHE1), and 4-hydroxyestrogens (4-OHE’s). As their parent estrogens, these estrogen metabolites exert different effects depending upon the tissue and cell one is examining. In fact, two estrogen metabolites in particular, 16-OHE1 and 2-OHE, have such contrasting cellular activities that 2-OHE is an estrogen antagonist. Yes, that is correct: there is an anti-estrogen, estrogen.
In recent years, so-called phytonutrients have become the focus of clinical research, as these natural compounds have shown the ability to modulate the body’s estrogen ratio. One of these phytonutrients, is a dietary indole known as indole-3-carbinol (I3C). Unfortunately, despite its metabolic usefulness, I3C is highly molecularly unstable, and therefore unsuitable for use as a therapeutic agent or dietary supplement.
N-Coumaroyldopamine is a natural analogue to the phytochemical N-Caffeoyldopamine, itself found prominently in various plants, including cocoa (Theobroma cacao L.). N-Coumaroyldopamine, its parent compounds, and other analogs that derive from its parent compound, have recently been the subject of phytochemical analyses due to their chemical similarity to sympathomimetic amines known to couple to the beta-2-adrenergic receptor.
Phytochemical analyses were subsequently designed to assess the potency of N-Coumaroyldopamine and N-Caffeoyldopamine as beta-2-adrenergic receptor agonists – or, in simpler terms, their ability to “turn on” the fabled beta-2-adrenergic receptor. In these trials, the phytochemicals were shown to be as potent as several well-known beta-2-adrenergic receptor agonists (salbutamol, procaterol, and fenoterol). You read that correctly: N-Coumaroyldopamine and N-Caffeoyldopamine were found to bind as tightly to the beta-2-adrenergic receptor as well known synthetic compounds!
The desirability of activating the beta-2-adrenergic receptor arises due to the critical role that beta-2-adrenertic receptors play in both skeletal muscle and adipose metabolic function. In particular, beta-2-adrenergic receptors have been shown to induce dilation in the vasculature (vasodilation – the process involved in a “pump”), increase oxygen uptake and nutrient transport to skeletal muscle, regulate thermogenesis (the production of body heat), inhibit the pro-adipogenic effects of other adrenergic receptor types, as well as directly increase lipolysis and the oxidation of fatty acids.
Beta-2-adrenergic receptors achieve these effects via one of the body’s key chemical messengers, known as cAMP (cyclic adenosine monophosphate). cAMP works as a sort of cell-type translator and foreman: it receives an input from, say, a receptor such as the beta-2-adrenergic receptor, and then communicates and directs the types of cells that the beta-2-adrenergic receptor would like to target.
Just within the context of beta-2-adrenergic agonism, this amounts to cAMP increasing resting metabolic rate and caloric expenditure (the amount of calories you burn), improving peripheral sensitivity to glucose and glucose utilization, reduction of gluconeogenesis, induction of AMPk (adenosine monophosphate kinase) release, triggering of lipolysis, the inhibition of lipogenesis, and vasodilation.
Or, in other words, cAMP is involved in nearly every beneficial physiological process that a lifter, runner, hiker, jumper, runner, tumbler, and fumbler would want. cAMP is involved in:
- Increasing bloodflow (“pump”).
- Reducing muscle protein usage (catabolism).
To say that cAMP is a desirable compound to increase the release of – which activating the beta-2-adrenergic receptor does – would qualify as the understatement of the year!
Luckily, however, I3C readily metabolizes into the secondary indole 3,3’ diindolylmethane, or DIM for short. When used in a supplemental fashion in clinical trials, DIM appears to possess all the positive effects of its parent compound.
DIM also exerts its own direct physiological effects, including:
- Adjusting the activity of certain cytochrome enzymes, reducing the activity at the estrogen receptor site.
- Limit the cell division and growth of certain estrogens.
Despite the bodybuilding community’s single-minded crusade to eliminate estrogen wherever it lie in wait, compounds such as DIM show us that estrogen is a very diverse set of compounds – and that we should actively pursue increasing certain estrogens that have beneficial, and ironically, anti-estrogenic effects.
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Core Nutritionals : Alpha
Unleash your inner ALPHA male with the ultra-potent Core ALPHA!
Core ALPHA is an all-natural, innovative product featuring ingredients backed by numerous clinical studies. Core ALPHA’s ingredients are all-natural and powerful, providing a safe and effective way to support healthy hormone function and balance.
- 2 capsules per serving.
- 28 servings per container.
- Hormone balance.
Take 1 capsule prior to your workout and 1 capsule before bed, preferably on an empty stomach. Alternatively, take 2 capsules at bedtime. Best when taken one hour prior to a meal or two hours after a meal. Do not use for longer than 8 continuous weeks without taking a 4 week break.
This product is only intended to be consumed by healthy adult males 21 years of age or older. This product is not recommended for women, especially those who are pregnant or nursing. Before using this product consult with your physician if you are using any prescription or over the counter medication or if you have any pre-existing medical condition including but not limited to: high or low blood pressure, cardiac arrhythmia, stroke, heart, liver, kidney or thyroid disease, seizure ...
Gelatin, magnesium stearate, silicon dioxide, FD&C blue #1, FD&C red #3, FD&C yellow #5, titanium dioxide.
Core Nutritionals : HMB
RESIST / REMAKE / POWER
HMB has been shown to:
- Attenuate the rate of muscle protein breakdown.
- Reduce muscle damage during periods of strenuous exercise.
- Increase power output during explosive movements
HMB (otherwise known as β-Hydroxy β-Methylbutyrate) is like the pretty girl who used to sit across from you in biology: sexy, mysterious, but most of all, pretty complex and little understood. And like that girl, the more you actually understand about this fascinating compound, the more you will like it.
HMB burst onto the bodybuilding market in the early 1990’s, and every supplement company and their brother marketed the compound so heavily it gained a reputation as snake oil. The reviews were so varied that HMB was almost relegated to the dustbin of supplement history.
Times have changed, however, and people have once again begun to realize that, when used properly at an effective serving, HMB’s positive contributions to a muscle-sparing environment are impossible to overlook.
HMB (β-Hydroxy β-Methylbutyrate) is an endogenous metabolite of leucine consumption, being derived from its parent amino acid through two steps of enzymatic conversion. In total, approximately 5% of leucine by weight of consumption is converted into HMB.
Once converted, HMB has been demonstrated to possess several interesting effects. In cellular assays, HMB was shown to increase the rate of skeletal protein synthesis through the same mechanism as its parent compound, leucine – the all-important mTOR-P13K pathway that regulates the majority of muscle protein synthesis in vivo. This mechanism has also translated into practical benefits to human muscle, as various trials have demonstrated HMB to slow the rate of skeletal muscle breakdown, increase power output over both acute (short) and chronic (long-term) trials, as well as mitigating muscle damage during high-intensity exercise.
Core - BOLIC
Natural athletes are often left with an impossible choice: accept that highly anabolic compounds come along with a host of negative side effects, disqualify them competition, and render them an “enhanced athlete,” or turn to these same compounds to reap their benefits on muscle anabolism and protein synthesis. A long line of supplements has purported to reconcile this problem, promising increases to muscle protein synthesis and nitrogen synthesis comparable to AAS (anabolic androgenic steroids). Such promises, of course, were empty, as the real-world effects of these compounds never matched the laboratory results.
These results suggest that PeakO2 may have beneficial effects on:
- Workout duration
- Time to exhaustion
- Maximum power output
- Peak strength
- Anaerobic peak power
- Oxygen utilization during exercise
- Ability to uptake oxygen
- Exercise capacity
Laxogenin appears to be different. While no natural compound will deliver the same effects as PEDs (performance enhancing drugs), and it’s irresponsible to suggest otherwise, Laxogenin does, in fact, seem to operate through the same mechanism of action that makes these compounds so effective – the so-called PI3K/Akt signaling pathway. This pathway directly regulates a process known as “protein turnover,” the ratio between protein synthesis (where your body “builds” muscle tissue) and protein degradation (where your body “destroys” muscle tissue to feed other physiologic processes). In situations where protein synthesis exceeds degradation, your body is in a state of ‘net positive protein turnover,’ commonly known as “anabolism.” While the data is still emerging, Laxogenin appears to induce this very state by significantly enhancing protein synthesis through the very same PI3K/Akt pathway. These trials show Laxogenin simultaneously reducing protein degradation, perhaps inducing muscle into a state of net positive protein turnover.
Combined with the patented ingredient Peak O2, clinically demonstrated to increase power output, endurance, and other metrics of exercise performance, BOLIC is a fully natural but fully effective performance supplement. It not only increases exercise performance, but makes the underlying response to exercise more efficient – ensuring that your hardwork is paying off!
Laxogenin, also known as 5a-hydroxy laxogenin is plant-based steroid derived Smilax sieboldii. Laxogenin is part of the Brassinosteroid class of plant hormones, polyhydroxylated derivatives 5a-cholestane – and thus is structurally to the cholesterol-backbone steroid hormones found in animals and ecdysteroids found in insects. Brassinosteroids function in plant tissue as steroid hormones function in animal tissue, namely by stimulating protein synthesis and inhibiting protein degradation via the PI3K/Akt signaling cascade. Unlike steroid hormones, however, both Brassinosteroids generally, and 5a¬¬-hydroxy laxogenin specifically, show no binding affinity to the androgen receptor (AR) in vitro.
While evidence is still emerging, the extant animal data on Laxogenin is promising. In a trial in healthy rats fed a protein-controlled diet (39.4% protein content), oral administration of Laxogenin “increased food intake, body weight gain…[and]…lean body mass.” Upon dissecting the animals, researchers demonstrated that both phenotypic variation and muscle hypertrophy occurred. Laxogenin “significantly increased” Type IIa and IIx muscle fibre phenotype and increased Type I and Type IIa cross-section. As noted above, Laxogenin dose- and time-dependently increased Akt phosphorylation in rat muscle cells at levels similar (though less) than insulin and IGF-1 controls. Protein synthesis as a result PI3K/Akt activation increased by approximately 35%, while protein degradation decreased by approximately 9% - suggesting that administration of Laxogenin promotes net positive protein conservation in animal muscle.
PeakO2™ is an organic-certified combination of six Ayurvedic mushroom strains extracted for their principal bioactives (Cordyceps militaris (Cordyceps), Ganoderma lucidim (Reishi), Pleurotus eryngii (King Trumpet), Lentinula edodes (Shiitake),Hericium erinaceus (Lions Mane), and Trametes versicolor (Turkey Tail).
The results of several human clinical trials on this compound suggest that it may meaningfully and dose-dependently impact several key metrics in exercise performance and physiology. A recent trial on 13 healthy, exercising adults consuming either 1.3 grams of PeakO2 or placebo, for example, demonstrated significant increases to oxygen kinetics, aerobic power and time to fatigue. In the adults receiving the 1.3g of PeakO2 for three weeks, VO2max (a measure of aerobic capacity) increased by 11% as compared to 1.8% in placebo; TTE (total time to exhaustion) increased by 8.2%; and peak power increased by 10%.
The results were similar in an additional study with 40 healthy adults, provided both low and high-dose PeakO2 for 28 days and compared with placebo. In this trial, participants receiving the mushroom extract experienced statistically significant increases to both VO2max and heart-rate economy – suggesting that PeakO2’s effects are both systemic and cumulative. That is, not only does PeakO2 exert its effects on the entirety of the human cardiovascular system – likely due to the multiple mechanisms of action in the mushroom blend – but these effects accumulate over time.
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